ID   M4RQA9_9BIFI            Unreviewed;      1209 AA.
AC   M4RQA9;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   SubName: Full=von Willebrand factor type A {ECO:0000313|EMBL:AGH40717.1};
GN   ORFNames=D805_0450 {ECO:0000313|EMBL:AGH40717.1};
OS   Bifidobacterium thermophilum RBL67.
OC   Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC   Bifidobacteriaceae; Bifidobacterium.
OX   NCBI_TaxID=1254439 {ECO:0000313|EMBL:AGH40717.1, ECO:0000313|Proteomes:UP000011835};
RN   [1] {ECO:0000313|EMBL:AGH40717.1, ECO:0000313|Proteomes:UP000011835}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RBL67 {ECO:0000313|EMBL:AGH40717.1,
RC   ECO:0000313|Proteomes:UP000011835};
RX   PubMed=23640377;
RA   Jans C., Lacroix C., Follador R., Stevens M.J.;
RT   "Complete Genome Sequence of the Probiotic Bifidobacterium thermophilum
RT   Strain RBL67.";
RL   Genome Announc. 1:E00191-13(2013).
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DR   EMBL; CP004346; AGH40717.1; -; Genomic_DNA.
DR   RefSeq; WP_015449979.1; NC_020546.1.
DR   AlphaFoldDB; M4RQA9; -.
DR   KEGG; btp:D805_0450; -.
DR   PATRIC; fig|1254439.12.peg.451; -.
DR   eggNOG; COG2304; Bacteria.
DR   eggNOG; COG2885; Bacteria.
DR   HOGENOM; CLU_269887_0_0_11; -.
DR   Proteomes; UP000011835; Chromosome.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProt.
DR   CDD; cd20742; FIX_vWA-like; 1.
DR   CDD; cd00198; vWFA; 1.
DR   Gene3D; 3.40.1350.110; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   Gene3D; 4.10.1080.10; TSP type-3 repeat; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR031965; CBM26.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR028974; TSP_type-3_rpt.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR37467; EXPORTED CALCIUM-BINDING GLYCOPROTEIN-RELATED; 1.
DR   PANTHER; PTHR37467:SF1; EXPORTED CALCIUM-BINDING GLYCOPROTEIN-RELATED; 1.
DR   Pfam; PF16738; CBM26; 3.
DR   Pfam; PF18884; TSP3_bac; 6.
DR   Pfam; PF13519; VWA_2; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF103647; TSP type-3 repeat; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..1209
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004057341"
FT   DOMAIN          578..749
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          325..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          828..885
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        394..420
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        856..885
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1209 AA;  130851 MW;  32D115210C1F6400 CRC64;
     MRGSRLSCVL CALLSMFMVM PASVASAATD GSGGSGEVTI HYYDSAGWAK PFAYMYGDGV
     RSASWPGERM TDDGDGWYSV TVDAPHGLRV LFSDNGKSQH PGANQPGYEV NGEAWFVGST
     RHDSMPEGMK VHFYDYANWG KVRLYYYSEA ARGPTWPGEA MHADGDGWYT ATIFGTQPAR
     VLFNDGGSRQ TPASGQEGHL VTAEAWCRNG VWTDTRPDGV LVMFHKPSGW GSPRIYYYTS
     DADTGPAWPG NAMKHMADGW YSYTITKYAK ARVLFNDGGH QVPAKSAPGY EASGVCRWDG
     GDWSCGDPAI DGDDDGVPDV LGMMLGGDSD TDGDGLPDAF ETIRTGTDPS RADSDGDGVA
     DGDEDPDGDG LTNLNEREIG TDPMAADTDG DGLTDGEETT RTHTDPLKSD TDGDGVDDRR
     EIQWGTDPLV PQETFDVTAP AEDVGQGDVD VSVSVNLPAS QAATLDVRRY DNPSYFPDDM
     PGLIGDAYEF TVDGQVGSAT LRFRFDESLL SDSSFDPAIC WFDEKEQRLE ELDTTVTGNE
     ATATVSHFSK YVLVNRTTFH DSFSWEDVWG DEQFNAVQTV FVIDDSGSMW SNDRGKKRLS
     VARDLVGRFP GNTRTGVVRF ADGATDLTGG LTDAQTAKNA LADANFHDSG GTSMYLAVRQ
     ALNMFQGDDD ATLRNIIVLS DGETADTRLH DSVVAEANKR KVKINAVGLG GGGPGSYFER
     WMKPLASQTG GESYLAQDAD ALAGIYENIG KLIDIETDSD GDGIPDWYED HLVLFNGVSL
     KLDKNNPDTD GDGIPDGEEI DRLDYRYNAD RTKVIVTGRL ITNPTLVDSY GDGIADADEP
     DPTTDPMNPD TDGDGLTDGD EVRRNFDPTS PDPDGDGRRD DRELADDTSP YVYDKAWYEQ
     FACFVVGALA GDFITDDDDP VTLAGQIIGG VIPTSDVRDA IANVKHGDYA FAAISAAGIV
     PAAGDAAKGA AKAGRFILRN IDDPAKAARL LAILEESCPS VVAKLGGSDG FVKAAASFSQ
     TGHARLTKKE KQHLVKAVNK AGLAKHLVTS GRDLPIAATI DTGKNVWNER WLKRGDIIDE
     HLNGHSTGRG LGRTFPVADR LENRVLVSTK SLDLDARSYQ TPGRLRSRLN KYVKDLEGFE
     DKYFNKVDGN GNKYMYWGKE KFTANKYDSK MLEVVFPDTA IGNDIAEALR AFQREHAGTG
     MQIVYKIAK
//