ID M4S631_9SPHN Unreviewed; 560 AA.
AC M4S631;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Na+/H+ antiporter {ECO:0000313|EMBL:AGH50403.1};
GN ORFNames=G432_13425 {ECO:0000313|EMBL:AGH50403.1};
OS Sphingomonas sp. MM-1.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=745310 {ECO:0000313|EMBL:AGH50403.1, ECO:0000313|Proteomes:UP000011816};
RN [1] {ECO:0000313|EMBL:AGH50403.1, ECO:0000313|Proteomes:UP000011816}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MM-1 {ECO:0000313|EMBL:AGH50403.1};
RX PubMed=23682148;
RA Tabata M., Ohtsubo Y., Ohhata S., Tsuda M., Nagata Y.;
RT "Complete Genome Sequence of the gamma-Hexachlorocyclohexane-Degrading
RT Bacterium Sphingomonas sp. Strain MM-1.";
RL Genome Announc. 1:E00247-13(2013).
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000256|RuleBase:RU366002}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|RuleBase:RU366002}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU366002}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU366002}.
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DR EMBL; CP004036; AGH50403.1; -; Genomic_DNA.
DR AlphaFoldDB; M4S631; -.
DR STRING; 745310.G432_13425; -.
DR KEGG; sphm:G432_13425; -.
DR PATRIC; fig|745310.14.peg.2797; -.
DR eggNOG; COG0025; Bacteria.
DR HOGENOM; CLU_005912_6_3_5; -.
DR Proteomes; UP000011816; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR NCBIfam; TIGR00831; a_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU366002};
KW Cell inner membrane {ECO:0000256|RuleBase:RU366002};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU366002};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366002};
KW Reference proteome {ECO:0000313|Proteomes:UP000011816};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU366002};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU366002};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366002}.
FT TRANSMEM 17..38
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 50..67
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 73..90
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 102..125
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 131..153
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 201..222
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 258..275
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 296..318
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 330..353
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 373..397
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 409..433
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT DOMAIN 25..434
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
SQ SEQUENCE 560 AA; 59992 MW; 719A774D43ABF949 CRC64;
MSAGDAPQAT VDASEGISLE TITIILILLL AVVVSGVVSR MLPLPVPRPL VQIALGGVIG
LAANWRVTLD PEIFFLLFLP PLLFLDGWRI PREELFKDGK TVLELALGLV VFTVLGMGLI
INWMIPAMPL PVAFALAAVI SPTDPIAVSA IAQRVPIPKR MMHILEGESL LNDASGLVCL
RFAVAAALTG VFSIGDAALN FLWVALGGIA IGAGVTFLVV RIKAGVSGRF GEDSGSQILI
SLLIPFGAYL VAEHLHCSGI LAAVAAGLAM GFAEGSAQAM AATRIRRNTV WDAIQFTANG
IIFVLLGEQL PLILAGAAET VRITGHHEPG WLAVYVLAIN LGLAALRFIW VWVSFRFTLL
THGRTRQQPN WRLVAAMSFA GVRGAITLAG VLTLPLAMAD GSPFPARDLA IFLAMGVIIV
SLIVASIGLP WLLKGLEMPA ESSQLAEIEA ARIAAAKAAI AEVERVEHVL AEGQEDADLY
VEIAGRIMDI YRRRIETRSP IAEDAAAARR VDRIEKELRL AALRAERAEI TRRSRQRELG
SDGARKLIRE LDLMETRYAG
//
