ID M4U4Y4_9GAMM Unreviewed; 812 AA.
AC M4U4Y4;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN ORFNames=PCNPT3_06855 {ECO:0000313|EMBL:AGH81309.1};
OS Psychromonas sp. CNPT3.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Psychromonadaceae; Psychromonas.
OX NCBI_TaxID=314282 {ECO:0000313|EMBL:AGH81309.1, ECO:0000313|Proteomes:UP000010320};
RN [1] {ECO:0000313|EMBL:AGH81309.1, ECO:0000313|Proteomes:UP000010320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CNPT3 {ECO:0000313|EMBL:AGH81309.1,
RC ECO:0000313|Proteomes:UP000010320};
RA Lauro F.M., Chastain R.A., Stratton T.K., Ferriera S., Johnson J.,
RA Yayanos A.A., Bartlett D.H.;
RT "The complete genome sequence of the deep-sea bacterium Psychromonas
RT CNPT2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR EMBL; CP004404; AGH81309.1; -; Genomic_DNA.
DR RefSeq; WP_015465188.1; NC_020802.1.
DR AlphaFoldDB; M4U4Y4; -.
DR STRING; 314282.PCNPT3_06855; -.
DR KEGG; psy:PCNPT3_06855; -.
DR eggNOG; COG0417; Bacteria.
DR HOGENOM; CLU_018487_0_0_6; -.
DR OrthoDB; 5807460at2; -.
DR Proteomes; UP000010320; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd05784; DNA_polB_II_exo; 1.
DR CDD; cd05537; POLBc_Pol_II; 1.
DR Gene3D; 2.40.50.590; -; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Reference proteome {ECO:0000313|Proteomes:UP000010320};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT DOMAIN 72..316
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 399..785
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 812 AA; 92028 MW; 05E1756B71834186 CRC64;
MSLSLPSSKQ LSGLLLSRQQ LETGFGVDLV FWFSTTQGPC RAVIKGQRYV FLVLQSDWPK
IEAACDESEL NIDEVRPLAL QSFSGEKVTA LYSLTGRQSR VLQKHIRQLG CRIFEADISI
SDRYLMERFI YGSAQISGEF TWMGRYWSCQ HATLSPSKVV PSLKVVSLDI ECSPSQELYS
VGLTLNNSDA QGIFTSTPTS QSLLFMVGDG SLKSEMNIHW CENEWVLLNA LQTWFVDFDP
DIIIGWSVVQ FDMRLLLSRA KLYNLSLNIG RDGSMMRWRA HSNTNSQGTL TLNGRVVLDG
IELLKNASLH FDSFSLQFVS EKLLGEGKLD AEAMEWDKGL VIQRQFEQDR LALARYNLQD
CWLVERIFRK LKLLEYSIER AQLTGLALDR RGASVAAFSN LYLPLLHRSG YIAPNIGDIQ
AQHSPGGFVM DSKPGLYGWV LLLDFKSLYP SIIRTFKIDP MGMICGLLEK PSLSIEGFKG
ARFSREKHHL PAILDKLTRA REEAKKEGNQ PFQHAIKIIM NSMYGVLGSA GCRFHDTRLA
SSITLRGHQI MKDTRHFIEQ LESEHSLEVI YGDTDSTFIS LASCENLLQA QAQGKVLAKK
INNYWTARIA DEFSLPSYLE IEFESCFSQF FMPTLRGSDV GSKKRYVGLK TDESGEHLLF
KGLESVRSDW TQMAQIFQKQ IYKQLFAKQS IDALIINTVL RLKKGELDAQ LIYHKRLRRP
LQDYVKNIPP QVKAALFADQ KNAEKGRPLR YQNTGRIAYL ITVNGAQAKE YQCADIDYQH
YIDKQLKPIV DALAPVLNVN FEQLISAQGT LF
//
