ID M4U8A8_9GAMM Unreviewed; 639 AA.
AC M4U8A8;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=PCNPT3_07195 {ECO:0000313|EMBL:AGH81377.1};
OS Psychromonas sp. CNPT3.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Psychromonadaceae; Psychromonas.
OX NCBI_TaxID=314282 {ECO:0000313|EMBL:AGH81377.1, ECO:0000313|Proteomes:UP000010320};
RN [1] {ECO:0000313|EMBL:AGH81377.1, ECO:0000313|Proteomes:UP000010320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CNPT3 {ECO:0000313|EMBL:AGH81377.1,
RC ECO:0000313|Proteomes:UP000010320};
RA Lauro F.M., Chastain R.A., Stratton T.K., Ferriera S., Johnson J.,
RA Yayanos A.A., Bartlett D.H.;
RT "The complete genome sequence of the deep-sea bacterium Psychromonas
RT CNPT2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
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DR EMBL; CP004404; AGH81377.1; -; Genomic_DNA.
DR RefSeq; WP_015465256.1; NC_020802.1.
DR AlphaFoldDB; M4U8A8; -.
DR STRING; 314282.PCNPT3_07195; -.
DR KEGG; psy:PCNPT3_07195; -.
DR eggNOG; COG0550; Bacteria.
DR HOGENOM; CLU_002929_5_2_6; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000010320; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:AGH81377.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010320};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..134
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 639 AA; 71875 MW; 6BE51B096AE09A89 CRC64;
MKLYIAEKPS LGRAIAQALP KPHRKAEGCI HVGNGDIVSW CIGHLLTQVD PEDYQEAFKK
WKFEHLPIIP EQWKLKSVAR TRKQLSVLKK LIKQADQLIH VGDPDREGQL LVDEVIHFSG
VRAAKLKQVQ RCLISDLTLN AVKRSLQSLR SNQEFIALST SALARTRADW LYGLNLTRVY
TLQAQKSGYK GVISVGRVQT PLLGLVVRRD LEIERFVSKP FYEVEAHLEG SQQNALALFT
AKWKPSAACQ QYQDAEGRVI VKGLAENVAQ RITGQDAIVK EFSAKNKKQT PPLPYNLSGL
QIDAAKRYHY SAQQVLDVCQ TLYERYQLIT YPRSDSRYLP NNHHQQAPSI ARAITHNTST
LSAAVAGADL SIKGRAWNDA KVDAHHAIIP TDSHKSLSSL DQMSQNIYYL IARQYLCQFY
PDHTYAQCVA EIEINKGLFV SKAKAKLEDG WKVLFNTQEK DTFLPNLSKG QRLFCNKGQV
IEKNTQAPQH FNDATLLAAM SKISRYVKDK GLKGILKDTD GLGTEATRAG IIELLFKRQF
LKRVGKTIEA SEVGRKLIES LPELLTLPDM TAQWEMQLNA ISLKKQSYNG FIVPLEKQLK
IIIDKAIKDG PQALSQLPST GGTFKKTYRK KRGVANKKR
//
