ID M4X455_9PSED Unreviewed; 703 AA.
AC M4X455;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Short chain enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:AGI25827.1};
GN ORFNames=H681_19800 {ECO:0000313|EMBL:AGI25827.1};
OS Pseudomonas sp. ATCC 13867.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=1294143 {ECO:0000313|EMBL:AGI25827.1, ECO:0000313|Proteomes:UP000012082};
RN [1] {ECO:0000313|EMBL:AGI25827.1, ECO:0000313|Proteomes:UP000012082}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13867 {ECO:0000313|EMBL:AGI25827.1,
RC ECO:0000313|Proteomes:UP000012082};
RX PubMed=23723394;
RA Ainala S.K., Somasundar A., Park S.;
RT "Complete genome sequence of Pseudomonas denitrificans ATCC 13867.";
RL Genome Announc. 1:E00257-E00213(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; CP004143; AGI25827.1; -; Genomic_DNA.
DR RefSeq; WP_015478679.1; NC_020829.1.
DR AlphaFoldDB; M4X455; -.
DR STRING; 1294143.H681_19800; -.
DR KEGG; pdr:H681_19800; -.
DR PATRIC; fig|1294143.3.peg.4017; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_009834_16_3_6; -.
DR OrthoDB; 5389341at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000012082; Chromosome.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140}.
FT DOMAIN 300..476
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 481..574
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 609..698
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 703 AA; 76496 MW; B62DFCE8941B9152 CRC64;
MSELIQYRLE DGVAFVGLCR APVNALSQRL RAAILSACER AAADAEVKAI ILHGADGLFC
AGADIAEFGT DAAFAEPSLP DTLMRISEID KPVIAAIGKL ALGGGLELAL ACGYRVGEPG
TRVGLPEINL GLLPGAGGTQ RLPRLIGAES ALNLILSGEQ IDAERARLLG ILDRLASEAK
HLLDEAETYA RELIAMSAPA LPPEHCPRPA EDLPDGFFAS FRERQESLWK NRLAPRLVLA
AVEAACLLPL REGLARELSL FKQAEASSQS QALRHVFFAE REAGRIPNIA PDLPLRSIRK
VAVIGAGTMG GGIAMNFVNA GIPVMLLEQQ GAALDRGLTM IRKNYEISVK RGKLSADQVE
ARMELLHGTL DYAELADADL VIEAVFEKME IKQQVFRTLD RVCKPGAILA TNTSSLDVDA
IAMSVSRPQD VIGLHFFSPA NVMRLLEVVR GKATAPDVLA TTMAIAKRIG KLAVVSGVCF
GFIGNRMLEP YSREAQRLLL EGATPAQVDK VLTELGLNMG IFSMQDLAGV DVLYLIRQAN
QAATAHDESY CRIGDELTVL KRHGQKSGRG FYRYEGRERQ EDPEVVALAE RLSQELNISR
RAVCDEEIHD RCLFMLINEG IQLLDEGIAL RASDIDLVWI NGYGFPAHLG GPMHYAEQLG
LERVLASIQR YRSELGAYGE MWFQPAPLLK RLVAAGKTRI ERF
//