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Database: UniProt
Entry: M4YLB6_THEXX
LinkDB: M4YLB6_THEXX
Original site: M4YLB6_THEXX 
ID   M4YLB6_THEXX            Unreviewed;       198 AA.
AC   M4YLB6;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   08-MAY-2019, entry version 30.
DE   RecName: Full=Probable thymidylate kinase {ECO:0000256|HAMAP-Rule:MF_00165};
DE            EC=2.7.4.9 {ECO:0000256|HAMAP-Rule:MF_00165};
DE   AltName: Full=dTMP kinase {ECO:0000256|HAMAP-Rule:MF_00165};
GN   Name=tmk {ECO:0000256|HAMAP-Rule:MF_00165};
GN   ORFNames=TALC_00143 {ECO:0000313|EMBL:AGI47157.1};
OS   Thermoplasmatales archaeon (strain BRNA1).
OC   Archaea; Euryarchaeota; Diaforarchaea group; Thermoplasmata;
OC   Thermoplasmatales.
OX   NCBI_TaxID=1054217 {ECO:0000313|EMBL:AGI47157.1, ECO:0000313|Proteomes:UP000012076};
RN   [1] {ECO:0000313|EMBL:AGI47157.1, ECO:0000313|Proteomes:UP000012076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BRNA1 {ECO:0000313|EMBL:AGI47157.1,
RC   ECO:0000313|Proteomes:UP000012076};
RA   Denman S.E., Evans P., Bragg L., Padmanahba J., McKenzie M.,
RA   Edwards D., Krzycki J., McSweeney C., Morrison M.;
RT   "Thermoplasmatales-like gut symbionts are pyrrolysine dependent-
RT   methanogens.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC         ChEBI:CHEBI:456216; EC=2.7.4.9; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00165};
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00165}.
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DR   EMBL; CP002916; AGI47157.1; -; Genomic_DNA.
DR   RefSeq; WP_015491674.1; NC_020892.1.
DR   STRING; 1054217.TALC_00143; -.
DR   EnsemblBacteria; AGI47157; AGI47157; TALC_00143.
DR   GeneID; 15077448; -.
DR   KEGG; tar:TALC_00143; -.
DR   PATRIC; fig|1054217.5.peg.134; -.
DR   KO; K00943; -.
DR   OMA; FLYTADH; -.
DR   OrthoDB; 114844at2157; -.
DR   BioCyc; TARC1054217:TALC_RS00675-MONOMER; -.
DR   Proteomes; UP000012076; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   InterPro; IPR018095; Thymidylate_kin_CS.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
DR   PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00165};
KW   Complete proteome {ECO:0000313|Proteomes:UP000012076};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00165, ECO:0000313|EMBL:AGI47157.1};
KW   Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00165};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00165};
KW   Reference proteome {ECO:0000313|Proteomes:UP000012076};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000313|EMBL:AGI47157.1}.
FT   DOMAIN        8    183       Thymidylate_kin. {ECO:0000259|Pfam:
FT                                PF02223}.
FT   NP_BIND      10     17       ATP. {ECO:0000256|HAMAP-Rule:MF_00165}.
SQ   SEQUENCE   198 AA;  21595 MW;  A869FBC5C83250AF CRC64;
     MKGRFIVLEG IDGSGKTTLA KRLAADAGDA WVTFEPTDGK IGSALRSGEY GDIPPAAEAL
     LFAADRSIHT AEIAKALDGG RWVICDRYMG STVAYQSASM GDSADWDWLV SMQKDAVIQP
     DAVILLDMDP EVSMSRVGNR GEELSRFEKL EFQRRVRDAY LRLAQMFGYI VIDASKDADS
     VYEEAVSALK GRGLFASE
//
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