ID M4YLF8_THEXX Unreviewed; 391 AA.
AC M4YLF8;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=hydroxymethylglutaryl-CoA reductase (NADPH) {ECO:0000256|ARBA:ARBA00012999};
DE EC=1.1.1.34 {ECO:0000256|ARBA:ARBA00012999};
GN ORFNames=TALC_00910 {ECO:0000313|EMBL:AGI47905.1};
OS Thermoplasmatales archaeon (strain BRNA1).
OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales.
OX NCBI_TaxID=1054217 {ECO:0000313|EMBL:AGI47905.1, ECO:0000313|Proteomes:UP000012076};
RN [1] {ECO:0000313|EMBL:AGI47905.1, ECO:0000313|Proteomes:UP000012076}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BRNA1 {ECO:0000313|EMBL:AGI47905.1,
RC ECO:0000313|Proteomes:UP000012076};
RA Denman S.E., Evans P., Bragg L., Padmanahba J., McKenzie M., Edwards D.,
RA Krzycki J., McSweeney C., Morrison M.;
RT "Thermoplasmatales-like gut symbionts are pyrrolysine dependent-
RT methanogens.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-mevalonate + CoA + 2 NADP(+) = (3S)-hydroxy-3-
CC methylglutaryl-CoA + 2 H(+) + 2 NADPH; Xref=Rhea:RHEA:15989,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:36464, ChEBI:CHEBI:43074,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.34;
CC Evidence={ECO:0000256|ARBA:ARBA00000020};
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661}.
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DR EMBL; CP002916; AGI47905.1; -; Genomic_DNA.
DR AlphaFoldDB; M4YLF8; -.
DR STRING; 1054217.TALC_00910; -.
DR KEGG; tar:TALC_00910; -.
DR PATRIC; fig|1054217.5.peg.861; -.
DR eggNOG; arCOG04260; Archaea.
DR HOGENOM; CLU_001734_2_2_2; -.
DR Proteomes; UP000012076; Chromosome.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR CDD; cd00643; HMG-CoA_reductase_classI; 1.
DR Gene3D; 3.30.70.420; Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR InterPro; IPR023076; HMG_CoA_Rdtase_CS.
DR InterPro; IPR004554; HMG_CoA_Rdtase_eu_arc.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR NCBIfam; TIGR00533; HMG_CoA_R_NADP; 1.
DR PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR PRINTS; PR00071; HMGCOARDTASE.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR PROSITE; PS00066; HMG_COA_REDUCTASE_1; 1.
DR PROSITE; PS00318; HMG_COA_REDUCTASE_2; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AGI47905.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000012076}.
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 391 AA; 40883 MW; E542B11BE966F657 CRC64;
MGRPMTDGTG LKNRGHSHAD VDERRAAAEQ FTGATLERVG KYCFSSEDAA HNCENMIGAV
QIPLGYAGPV KINGEYAQGE FLVPMATTEG ALIASVSRGM SVMNDAGGVR AKTFGDYMTR
APVLRVRDLE HSCQVIQWID AHGDEMRQAV AGTTSHGKLV KIEKFPTGRN LYLRFSFETG
DAMGMNMATI ASEAVCRLIE QETGAVMVSV SGNMCSDKKP AAINMIEGRG KTVVAEALIP
ADIVEKRLHA SASAIVETNI RKNLIGSSMA GMLGANAHAA NMVAAVFLAT GQDPAQVTEG
ALTLTDCEDV DGSLYISVRM PSIEVGTVGG GTSLPTQAEA LNMIGCKGAG KARKLAEIIA
ATVLAGELST LAAQAAGQLG KAHAELGRGK K
//
