GenomeNet

Database: UniProt
Entry: M4YPN2_THEXX
LinkDB: M4YPN2_THEXX
Original site: M4YPN2_THEXX 
ID   M4YPN2_THEXX            Unreviewed;       337 AA.
AC   M4YPN2;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   SubName: Full=Pyruvate-formate lyase-activating enzyme {ECO:0000313|EMBL:AGI48372.1};
DE            EC=1.97.1.4 {ECO:0000313|EMBL:AGI48372.1};
GN   ORFNames=TALC_01394 {ECO:0000313|EMBL:AGI48372.1};
OS   Thermoplasmatales archaeon (strain BRNA1).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales.
OX   NCBI_TaxID=1054217 {ECO:0000313|EMBL:AGI48372.1, ECO:0000313|Proteomes:UP000012076};
RN   [1] {ECO:0000313|EMBL:AGI48372.1, ECO:0000313|Proteomes:UP000012076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BRNA1 {ECO:0000313|EMBL:AGI48372.1,
RC   ECO:0000313|Proteomes:UP000012076};
RA   Denman S.E., Evans P., Bragg L., Padmanahba J., McKenzie M., Edwards D.,
RA   Krzycki J., McSweeney C., Morrison M.;
RT   "Thermoplasmatales-like gut symbionts are pyrrolysine dependent-
RT   methanogens.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|PIRSR:PIRSR004869-50};
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine.
CC       {ECO:0000256|PIRSR:PIRSR004869-50};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP002916; AGI48372.1; -; Genomic_DNA.
DR   AlphaFoldDB; M4YPN2; -.
DR   STRING; 1054217.TALC_01394; -.
DR   KEGG; tar:TALC_01394; -.
DR   PATRIC; fig|1054217.5.peg.1325; -.
DR   eggNOG; arCOG00946; Archaea.
DR   HOGENOM; CLU_044176_1_0_2; -.
DR   OMA; YHFYPGS; -.
DR   Proteomes; UP000012076; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0043365; F:[formate-C-acetyltransferase]-activating enzyme activity; IEA:UniProtKB-EC.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd01335; Radical_SAM; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR027596; AmmeMemoSam_rS.
DR   InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR   InterPro; IPR034457; Organic_radical-activating.
DR   InterPro; IPR016431; Pyrv-formate_lyase-activ_prd.
DR   InterPro; IPR007197; rSAM.
DR   NCBIfam; TIGR04337; AmmeMemoSam_rS; 1.
DR   PANTHER; PTHR30352:SF5; PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME; 1.
DR   PANTHER; PTHR30352; PYRUVATE FORMATE-LYASE-ACTIVATING ENZYME; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   PIRSF; PIRSF004869; PflX_prd; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SFLD; SFLDG01101; Uncharacterised_Radical_SAM_Su; 1.
DR   SMART; SM00729; Elp3; 1.
DR   SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   4: Predicted;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR004869-50};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|PIRSR:PIRSR004869-
KW   50}; Lyase {ECO:0000313|EMBL:AGI48372.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR004869-50};
KW   Oxidoreductase {ECO:0000313|EMBL:AGI48372.1};
KW   Pyruvate {ECO:0000313|EMBL:AGI48372.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000012076};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PIRSR:PIRSR004869-50}.
FT   DOMAIN          72..284
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000259|PROSITE:PS51918"
FT   BINDING         87
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR004869-50"
FT   BINDING         91
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR004869-50"
FT   BINDING         94
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR004869-50"
SQ   SEQUENCE   337 AA;  38299 MW;  76224BEB369E683F CRC64;
     MAFINPNHPA KYWHSEGTDC VCDLCPHHCR IKKDGFGLCN SRKNVEGRLV AYNYGRISSI
     AVDPIEKKPL YHYYPATSVF SVGGIGCNLR CQYCQNYPIS MDAFGKKRTT YKSPEDIVAL
     CRQQKFGRIA FTYNEPSIWY EYIMDVMEED PDLDLVLVTN GMIEEEPLRD LCKVTGAMNI
     DVKAFNESFY SKLCGGKLEY VKKTCEIVHA SKVHLELTYL VIPGYNDDED DILEFVKWVR
     DSLSPDVPVH FNRFHPDYNM MTVPMTPAET LLRCKEIAED NGLNYAYVGN ILADDATDTY
     CPECGASVIK RTGYSVSILG LDGDRCAFCK HKLNIVR
//
DBGET integrated database retrieval system