ID M4YQY9_THEXX Unreviewed; 430 AA.
AC M4YQY9;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=O-acetylhomoserine sulfhydrolase {ECO:0000313|EMBL:AGI48438.1};
DE EC=2.5.1.49 {ECO:0000313|EMBL:AGI48438.1};
GN ORFNames=TALC_01463 {ECO:0000313|EMBL:AGI48438.1};
OS Thermoplasmatales archaeon (strain BRNA1).
OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales.
OX NCBI_TaxID=1054217 {ECO:0000313|EMBL:AGI48438.1, ECO:0000313|Proteomes:UP000012076};
RN [1] {ECO:0000313|EMBL:AGI48438.1, ECO:0000313|Proteomes:UP000012076}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BRNA1 {ECO:0000313|EMBL:AGI48438.1,
RC ECO:0000313|Proteomes:UP000012076};
RA Denman S.E., Evans P., Bragg L., Padmanahba J., McKenzie M., Edwards D.,
RA Krzycki J., McSweeney C., Morrison M.;
RT "Thermoplasmatales-like gut symbionts are pyrrolysine dependent-
RT methanogens.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077}.
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DR EMBL; CP002916; AGI48438.1; -; Genomic_DNA.
DR AlphaFoldDB; M4YQY9; -.
DR STRING; 1054217.TALC_01463; -.
DR KEGG; tar:TALC_01463; -.
DR PATRIC; fig|1054217.5.peg.1392; -.
DR eggNOG; arCOG00061; Archaea.
DR HOGENOM; CLU_018986_4_0_2; -.
DR Proteomes; UP000012076; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:AGI48438.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000012076};
KW Transferase {ECO:0000313|EMBL:AGI48438.1}.
SQ SEQUENCE 430 AA; 46571 MW; 32CCB4FC9A209FA8 CRC64;
MSDHKYKIET LQVHAGQESP DPTTDARAVP IYMTTSYVFK DSAQAAGRFA LAEPGNIYTR
LMNPTSSVFE ERMVALEGGI AALATASGAA AITYAVQNIA LAGDHIVSSS NVYGGTFNLF
ENTLREQGIE TTFVDPSDPK NFEKAIRENT KLLYTEVLGN PNSDVADIDE ISKIAHKHGI
PLIVDSTFTP PSVFRPIEHG ADIVVHSATK FIGGHGVAMG GIIIDSGNFD WAQNDKFPTL
SKPNPSYHGV VFTEAVGKAA FVVKIRTTLM RDQGAAISPF NSFLLLLGLE TLSLRTDRHI
ENALKVVDYL KNHPQVEKVN HPSLETGAKK AVYDRFFPKG AGSIFTFEIK GGAEKAKKFT
ESLKLFSLLA NVADVKSLVI HPASTTHSQL EEDALLASGI KPNTVRLSIG TENIDDIIAD
LEQGFAKIKE
//
