ID   M5D121_STEMA            Unreviewed;       925 AA.
AC   M5D121;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=SMSKK35_1250 {ECO:0000313|EMBL:CCP12219.1};
OS   Stenotrophomonas maltophilia SKK35.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Stenotrophomonas; Stenotrophomonas maltophilia group.
OX   NCBI_TaxID=1118156 {ECO:0000313|EMBL:CCP12219.1, ECO:0000313|Proteomes:UP000012178};
RN   [1] {ECO:0000313|EMBL:CCP12219.1, ECO:0000313|Proteomes:UP000012178}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SKK35 {ECO:0000313|EMBL:CCP12219.1,
RC   ECO:0000313|Proteomes:UP000012178};
RA   Linke B., Adamek M., Schwartz T.;
RT   "Stenotrophomonas maltophilia SKK35 and RA8 genome sequencing: analysis and
RT   comparison of viurlence genes.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCP12219.1}.
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DR   EMBL; CALN01000922; CCP12219.1; -; Genomic_DNA.
DR   AlphaFoldDB; M5D121; -.
DR   Proteomes; UP000012178; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   CDD; cd18807; SF1_C_UvrD; 1.
DR   Gene3D; 3.30.65.10; Bacterial Topoisomerase I, domain 1; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR022161; Helicase_IV_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF63; DNA HELICASE IV; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12462; Helicase_IV_N; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          218..683
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   BINDING         239..246
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   925 AA;  104002 MW;  6A23EFAD0376EB8B CRC64;
     MQGSIWMSME WRPSGWGQRV TRSPLWWLRL DGEHLELTLG GEQYRQHVDG DHRVQVVPGL
     FWARVALQTE RGPVSVGGLP NRQASHLAAA VQDVLSARST RGRRGLFEDV LAQIQAWLSA
     ADALTDRGHA SRRWITHEQQ QALLADRPAL PLSPDELERL FLDASVHDDL RSSRHLAALE
     ALNDWHLDWP AVWAEANDAM ATRELVLAKD FLDRVESRPL TEEQARAVIC FDNRVQVVAA
     AGSGKTSTMV AKAAYAIDRG FVEPERIVML AFNKDAAKEL EARAQRSFDR LGMGDTVVEA
     RTFHALGLAI IGKATGRKPD IPEWAIDATQ GFNKLAELVD DLKDRSIHFR TQWDMFRLVF
     GRDLPPFGAE MMADGYDRDG TPYIRTLQGE RVKSLEECVI ADWLFYNGVA YDYERRYEFD
     TATDTHHQYR PNFYYPDAAL YHEHFALDAN GQPPKHFAHY AESMHWKRQQ HVARGTALVE
     TTSFGLRSGH ALHDLAETLG ASDIELDPNP DRELPDVGAK PMPDADLIGL MRTFIAHAKS
     NCLTLDDMAA RLRQMPEDQF KERYRRFLEI AGPVFQAWDN ALADERGIDF EDMLNMAAGL
     LEQGHYASPY DLVLADEFQD ASRARARLCR ALVSQPGRHL FAVGDDWQSI NRFAGADVSV
     MTGFHEWMGH GQVLKLEQTF RCPQALCDVS SRFISRNPAQ IGKAVRSATP AMGPVLQAFQ
     MTRREEVQDG VRQYLTRLHQ QLLSGVVPRG RNGRITVFVL GRYQADRSAV PAEWRTSFGS
     TMEVEFLTAH RSKGREADYV ILPGMVNRSF PSLRSDDPVL SLAMPEGDSY PLSEERRLFY
     VALTRARRSV AMFTLQGKHS PFLDELVKDG AVEVTGISGA VINEERCPVC KVGVFVGRNG
     PHGPFRSCSS YPLCHNKPNA GYRRG
//