ID M5E2S3_9FIRM Unreviewed; 775 AA.
AC M5E2S3;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=Late competence protein ComEC, DNA transport {ECO:0000313|EMBL:CCU80472.1};
GN ORFNames=HSACCH_02064 {ECO:0000313|EMBL:CCU80472.1};
OS Halanaerobium saccharolyticum subsp. saccharolyticum DSM 6643.
OC Bacteria; Bacillota; Clostridia; Halanaerobiales; Halanaerobiaceae;
OC Halanaerobium.
OX NCBI_TaxID=1293054 {ECO:0000313|EMBL:CCU80472.1, ECO:0000313|Proteomes:UP000012063};
RN [1] {ECO:0000313|Proteomes:UP000012063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6643 {ECO:0000313|Proteomes:UP000012063};
RX PubMed=23640197; DOI=10.1128/genomea.00187-13;
RA Kivisto A., Larjo A., Ciranna A., Santala V., Roos C., Karp M.;
RT "Genome Sequence of Halanaerobium saccharolyticum subsp. saccharolyticum
RT Strain DSM 6643T, a Halophilic Hydrogen-Producing Bacterium.";
RL Genome Announc. 1:217-225(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCU80472.1}.
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DR EMBL; CAUI01000023; CCU80472.1; -; Genomic_DNA.
DR RefSeq; WP_005489746.1; NZ_CAUI01000023.1.
DR AlphaFoldDB; M5E2S3; -.
DR STRING; 1293054.HSACCH_02064; -.
DR eggNOG; COG0658; Bacteria.
DR eggNOG; COG2333; Bacteria.
DR InParanoid; M5E2S3; -.
DR OrthoDB; 9761531at2; -.
DR Proteomes; UP000012063; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000012063};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 33..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 530..730
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 775 AA; 88848 MW; 0FFFF9AB81FAFE5E CRC64;
MKITRRPAFM MAIALAAGLF SSYFLIIYEH LNILKIMIII EFIYLLLYLF YEFNFSKKSI
FILLIIICFI LGSILYAYQE YKYQSKFSII NFSDCGSCKV LAQILFDIGD LESNKIYLKP
YIINKQQVKY GKILITSEKL KKLSDGDLIF LELELSEPEA ALNPGGFDYS KYLKNKGVYL
QGWNTKQLRL IKKSNSIKNK IISFKKELLN NINALFNKEN AAFIKSILLG EKEYLSYKQE
ILLRNAGASH LLAISGLHMG IIILCFSFVL FKICSKKRYA LYLLSFFTLN YIILVGAAVS
IIRAAMLALL FLFSSEFNRE GDFLNIISIT LIINLILDPL SLFTVSLQLS YILVISLYYL
TPLLSSYISP VLAVSLSAQL ASLPIASYYF NEYAYIALIT NLWLIPYITI LLPFIFILVL
LSIFSLSFFQ PLALIIKIGL NFLFKGLEFM TLIQNKPLVI AKPELVIIIF YYLFLFSLPY
LYQKRYIYIK AKNYLFWKKI IPVFLVIIII SFFIKPVSNE LEVNFIAVGQ GDGIFIKFPN
GKNMLVDTGP PGNDGRNVEY NIISFLNNQG ISSLDYLMIS HFDADHAGGM PHLFQRKDIK
KILIPSFKEK TELHNILEKE IKKNKIKFNF LSSGMTFNIA DCRIDILNPD DNNLNEDRNE
NSIVFLLTHK ENTFLFTGDL SKKGEVRIIN KYNLAEVDVL KAGHHGSKTS SGEMFLNKIK
PKIIVISVGR NNFGHPSAEV IERYNKKSIK YFRTDKSGMI KFISDGNKIL VNTFR
//
