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Database: UniProt
Entry: M5EDG7_MALS4
LinkDB: M5EDG7_MALS4
Original site: M5EDG7_MALS4 
ID   M5EDG7_MALS4            Unreviewed;       836 AA.
AC   M5EDG7;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   02-DEC-2020, entry version 29.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=MSY001_3376 {ECO:0000313|EMBL:CCV00670.1}, MSYG_4282
GN   {ECO:0000313|EMBL:SHO79927.1};
OS   Malassezia sympodialis (strain ATCC 42132) (Atopic eczema-associated
OS   yeast).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX   NCBI_TaxID=1230383 {ECO:0000313|EMBL:CCV00670.1, ECO:0000313|Proteomes:UP000016925};
RN   [1] {ECO:0000313|EMBL:CCV00670.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 42132 {ECO:0000313|EMBL:CCV00670.1};
RA   Gioti A., Nystedt B., Li W., Xu J., Andersson A., Averette A.F., Muench K.,
RA   Wang X., Kappauf C., Kingsbury J.M., Kraak B., Johansson H., Holm T.,
RA   Lehtio J., Stajich J.E., Kahmann R., Kennell J.C., Cardenas-Corona M.,
RA   Lundeberg J., Saunders C.W., Boekhout T., Dawson T.L., Munro C., Groot P.,
RA   Butler G., Heitman J., Scheynius A.;
RT   "Genomic insights into the atopic eczema associated skin commensal yeast
RT   Malassezia sympodialis.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000016925}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42132 {ECO:0000313|Proteomes:UP000016925};
RX   PubMed=23341551; DOI=10.1128/mbio.00572-12;
RA   Gioti A., Nystedt B., Li W., Xu J., Andersson A., Averette A.F., Muench K.,
RA   Wang X., Kappauf C., Kingsbury J.M., Kraak B., Walker L.A., Johansson H.J.,
RA   Holm T., Lehtioe J., Stajich J.E., Mieczkowski P., Kahmann R.,
RA   Kennell J.C., Cardenas M.E., Lundeberg J., Saunders C.W., Boekhout T.,
RA   Dawson T.L., Munro C.A., de Groot P.W.J., Butler G., Heitman J.,
RA   Scheynius A.;
RT   "Genomic insights into the atopic eczema-associated skin commensal yeast
RT   Malassezia sympodialis.";
RL   MBio 4:E572-E572(2013).
RN   [3] {ECO:0000313|EMBL:SHO79927.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42132 {ECO:0000313|EMBL:SHO79927.1};
RA   Song W.-J., Kurnit D.M.;
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Proteomes:UP000186303}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42132 {ECO:0000313|Proteomes:UP000186303};
RX   PubMed=28100699; DOI=10.1093/nar/gkx006;
RA   Zhu Y., Engstroem P.G., Tellgren-Roth C., Baudo C.D., Kennell J.C., Sun S.,
RA   Billmyre R.B., Schroeder M.S., Andersson A., Holm T., Sigurgeirsson B.,
RA   Wu G., Sankaranarayanan S.R., Siddharthan R., Sanyal K., Lundeberg J.,
RA   Nystedt B., Boekhout T., Dawson T.L. Jr., Heitman J., Scheynius A.,
RA   Lehtioe J.;
RT   "Proteogenomics produces comprehensive and highly accurate protein-coding
RT   gene annotation in a complete genome assembly of Malassezia sympodialis.";
RL   Nucleic Acids Res. 45:2629-2643(2017).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; HE999574; CCV00670.1; -; Genomic_DNA.
DR   EMBL; LT671828; SHO79927.1; -; Genomic_DNA.
DR   RefSeq; XP_018741852.1; XM_018885276.1.
DR   EnsemblFungi; CCV00670; CCV00670; MSY001_3376.
DR   EnsemblFungi; SHO79927; SHO79927; MSYG_4282.
DR   GeneID; 30058260; -.
DR   KEGG; msym:MSY001_3376; -.
DR   HOGENOM; CLU_005230_0_0_1; -.
DR   OrthoDB; 181796at2759; -.
DR   Proteomes; UP000016925; Unassembled WGS sequence.
DR   Proteomes; UP000186303; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186303};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        422..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        468..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        540..559
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        571..595
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        647..667
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        768..795
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          53..80
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          103..137
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   836 AA;  94132 MW;  4F7A546DF3362E28 CRC64;
     MSDESLFRSA TMSLIQLYIP SESVHATVTE LGELGNIQFK DLNPDVAPFQ RTFVNEIRRL
     DEMDRRVQFL QEQLEREAIS VRPRESAAAF LPHEEHARGP MFMEELAKRL QEHEERVVQM
     NHSHDALQKR LLELEESKHV VRETEVFFRH AEAEPEHVRV SMDEDAHAPL LEGQGAGVRS
     LASRAPVDLE FVAGTIERSH MATLERVLWR ALRGNLYMNY AEIPAPFDDP AREEPVFKNV
     FVIFAHGAAV LAKIRKMCES MGGTLYPVES DAAQREARLH DVLERIEDHE NILYSTNAAR
     RTELVRVAES IAAWADVVRR EKLVYGTMNQ FQFDGNQKTL VAEGWVPRSD LSAVQLALRR
     ATETTGAHVS SVMQTMHTKE TPPTFQRTNK LTEGFQAIID AYGFATYQEA NPGLFTVITF
     PFLFAVMFGD LGHGVLMLLA AGAMVLYENK LLRTRLDEIT GMFFYGRYII LLMGAFAIFT
     GLMYNDVFSR SMHLFSSGWA WPRGTGTLTA QPTGRVYPVG VDPAWHGSDN NLVFTNSLKM
     KLSVVLGVAH MTFALLLNVP NHLHFKRASF IWAELVPQLL FLESLFGYLV VTIFYKWATN
     WYATDAAGAP LHNSPPGLLN MLIYMFLKPG VVEPDAQLYA GQASVQMGLL LLALVCVPWM
     LCAKPYLLWK EHQRRQGAGY HAVGSARGEQ RIHADEDDER ALAEELVDDE DEEEEFEIGE
     VVIHQIIHTI EFCLGCISNT ASYLRLWALS LAHAQLSQVL WDMTIKNVFG MTGLTGVLAT
     VFAFALWFVL TIAILCVMEG LSAFLHALRL HWVEGGSKHY EAAGYPFQPL SLAADL
//
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