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Database: UniProt
Entry: M5EK74_MALS4
LinkDB: M5EK74_MALS4
Original site: M5EK74_MALS4 
ID   M5EK74_MALS4            Unreviewed;      1021 AA.
AC   M5EK74;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   22-NOV-2017, entry version 19.
DE   SubName: Full=Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex {ECO:0000313|EMBL:SHO76431.1};
GN   Name=KGD1 {ECO:0000313|EMBL:SHO76431.1};
GN   ORFNames=MSY001_0694 {ECO:0000313|EMBL:CCU97988.1}, MSYG_0769
GN   {ECO:0000313|EMBL:SHO76431.1};
OS   Malassezia sympodialis (strain ATCC 42132) (Atopic eczema-associated
OS   yeast).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX   NCBI_TaxID=1230383 {ECO:0000313|EMBL:CCU97988.1, ECO:0000313|Proteomes:UP000016925};
RN   [1] {ECO:0000313|EMBL:CCU97988.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 42132 {ECO:0000313|EMBL:CCU97988.1};
RA   Gioti A., Nystedt B., Li W., Xu J., Andersson A., Averette A.F.,
RA   Muench K., Wang X., Kappauf C., Kingsbury J.M., Kraak B.,
RA   Johansson H., Holm T., Lehtio J., Stajich J.E., Kahmann R.,
RA   Kennell J.C., Cardenas-Corona M., Lundeberg J., Saunders C.W.,
RA   Boekhout T., Dawson T.L., Munro C., Groot P., Butler G., Heitman J.,
RA   Scheynius A.;
RT   "Genomic insights into the atopic eczema associated skin commensal
RT   yeast Malassezia sympodialis.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000016925}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42132 {ECO:0000313|Proteomes:UP000016925};
RX   PubMed=23341551; DOI=10.1128/mBio.00572-12;
RA   Gioti A., Nystedt B., Li W., Xu J., Andersson A., Averette A.F.,
RA   Muench K., Wang X., Kappauf C., Kingsbury J.M., Kraak B., Walker L.A.,
RA   Johansson H.J., Holm T., Lehtioe J., Stajich J.E., Mieczkowski P.,
RA   Kahmann R., Kennell J.C., Cardenas M.E., Lundeberg J., Saunders C.W.,
RA   Boekhout T., Dawson T.L., Munro C.A., de Groot P.W.J., Butler G.,
RA   Heitman J., Scheynius A.;
RT   "Genomic insights into the atopic eczema-associated skin commensal
RT   yeast Malassezia sympodialis.";
RL   MBio 4:E572-E572(2013).
RN   [3] {ECO:0000313|EMBL:SHO76431.1, ECO:0000313|Proteomes:UP000186303}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42132 {ECO:0000313|EMBL:SHO76431.1,
RC   ECO:0000313|Proteomes:UP000186303};
RA   Song W.-J., Kurnit D.M.;
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HE999551; CCU97988.1; -; Genomic_DNA.
DR   EMBL; LT671821; SHO76431.1; -; Genomic_DNA.
DR   RefSeq; XP_018739310.1; XM_018885770.1.
DR   EnsemblFungi; CCU97988; CCU97988; MSY001_0694.
DR   EnsemblFungi; SHO76431; SHO76431; MSYG_0769.
DR   GeneID; 30055579; -.
DR   OrthoDB; EOG092C0B3K; -.
DR   Proteomes; UP000016925; Unassembled WGS sequence.
DR   Proteomes; UP000186303; Chromosome 1.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   PANTHER; PTHR23152; PTHR23152; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   TIGRFAMs; TIGR00239; 2oxo_dh_E1; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000016925,
KW   ECO:0000313|Proteomes:UP000186303};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016925}.
FT   DOMAIN      643    853       Transket_pyr. {ECO:0000259|SMART:
FT                                SM00861}.
SQ   SEQUENCE   1021 AA;  115476 MW;  185B568FF8148AB4 CRC64;
     MLRQFHKAPM RAVTTSRVST VFARSAGCRM MTSSVRVMAG PIPKPSSPSP SDSFATTNNS
     YYAEEMYRRW KEDPKSVHSS WDVYFSGMDS GMPSQQAFTP APSQLSMPGT GTVTEPGSHP
     ANDYLKLQLL VRAFQVQGHK IAKIDPLRII DSERAEKMPK ELDPSYYGWS DSDLDKEMQL
     GTGLLPNFAA AGTTKLTIRE VIDACRRIYC GSIGYQYVHV PDRNQCDWLR EHLEVPKPFE
     YTKDEKWRIF DRLVWSDSFE RFIASKYPNE KRFGLEGGES MIPGVKTIID RAVETGVRNI
     TMGMPHRGRL NVLGNVIRRP LESILHQFAD KSNEEGGGDV KYHLGANYVR PTPSGEKVAL
     SLVANPSHLE AEDPVVLGKT RALQDFEGDK EHNKSMALLM HGDAAFAGQG VVYETMGMYN
     LPKFATGGTI HIIVNNQIGF TTDPRFARST PYPSDIAKGI DAPIFHVNGD DVEAVNYVCG
     LAVDWRTKFK KDVVIDLVCY RRHGHNEIDQ PSFTQPRMYE AIGKQLPTLK QYINRLVEEG
     TFTEKQLNDH CEWVWGMLQE AFEKSKTYEP EERQWLSSAW EGFPSPRELK EHILEQRETG
     VDVERLRYIG KASASFPEDF TVHRNLVRIL RNREKTLETG EGIDMSTAEA LAFGSLVMEN
     NMVRVSGQDV ERGTFSQRHA VLHDQKSENT YVPLQHLSDD QAPFTICNSS LSEFGALGFE
     LGFSLVDPKN LTIWEAQFGD FANNAQCIID QFIASGEHKW LQRTGLVVNL PHGYDGQGPE
     HSSARPERFL LLMDDHPYRF PNSEQVARQH QDANMAVVYC TTPANLFHVL RRQVHRDFRK
     PLINLFSKSL LRHPEARSKL EEMGPGTSFQ RVIPEPHETE GKDALVSPEQ IKRHILTVGQ
     SYYALLNHRR ENEIKDVAIT RIEQIAPLDY ETIVAALDKY PNADLMFAQE EPVNNGAWLY
     LEPRLRTLCT KTQHHKGREF MVSARPPSSS VATGNKGAHL AELRAYVNGA FDMNRSVHDE
     A
//
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