ID M5EPS2_MALS4 Unreviewed; 962 AA.
AC M5EPS2;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Lysophospholipase {ECO:0000256|RuleBase:RU362103};
DE EC=3.1.1.5 {ECO:0000256|RuleBase:RU362103};
GN ORFNames=MSYG_1137 {ECO:0000313|EMBL:SHO76798.1};
OS Malassezia sympodialis (strain ATCC 42132) (Atopic eczema-associated
OS yeast).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX NCBI_TaxID=1230383 {ECO:0000313|EMBL:SHO76798.1, ECO:0000313|Proteomes:UP000186303};
RN [1] {ECO:0000313|Proteomes:UP000186303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42132 {ECO:0000313|Proteomes:UP000186303};
RX PubMed=28100699; DOI=10.1093/nar/gkx006;
RA Zhu Y., Engstroem P.G., Tellgren-Roth C., Baudo C.D., Kennell J.C., Sun S.,
RA Billmyre R.B., Schroeder M.S., Andersson A., Holm T., Sigurgeirsson B.,
RA Wu G., Sankaranarayanan S.R., Siddharthan R., Sanyal K., Lundeberg J.,
RA Nystedt B., Boekhout T., Dawson T.L. Jr., Heitman J., Scheynius A.,
RA Lehtioe J.;
RT "Proteogenomics produces comprehensive and highly accurate protein-coding
RT gene annotation in a complete genome assembly of Malassezia sympodialis.";
RL Nucleic Acids Res. 45:2629-2643(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid +
CC H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;
CC Evidence={ECO:0000256|RuleBase:RU362103};
CC -!- SIMILARITY: Belongs to the lysophospholipase family.
CC {ECO:0000256|ARBA:ARBA00008780, ECO:0000256|RuleBase:RU362103}.
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DR EMBL; LT671822; SHO76798.1; -; Genomic_DNA.
DR RefSeq; XP_018740951.1; XM_018884275.1.
DR STRING; 1230383.M5EPS2; -.
DR GeneID; 30057309; -.
DR KEGG; msym:MSY001_2424; -.
DR VEuPathDB; FungiDB:MSYG_1137; -.
DR HOGENOM; CLU_013227_0_0_1; -.
DR OMA; IRHERPW; -.
DR OrthoDB; 1997175at2759; -.
DR Proteomes; UP000186303; Chromosome 2.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:UniProtKB-EC.
DR GO; GO:0102545; F:phosphatidyl phospholipase B activity; IEA:UniProtKB-EC.
DR GO; GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002642; LysoPLipase_cat_dom.
DR PANTHER; PTHR10728; CYTOSOLIC PHOSPHOLIPASE A2; 1.
DR PANTHER; PTHR10728:SF40; LYSOPHOSPHOLIPASE; 1.
DR Pfam; PF01735; PLA2_B; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR PROSITE; PS51210; PLA2C; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU362103};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963,
KW ECO:0000256|RuleBase:RU362103};
KW Lipid metabolism {ECO:0000256|RuleBase:RU362103};
KW Reference proteome {ECO:0000313|Proteomes:UP000186303}.
SQ SEQUENCE 962 AA; 107064 MW; 659B89DB70C55DEE CRC64;
MGLVHRIRSS PSYLFIKCYL ICTLVTLFAA RPLSSRLNAN GPWTWYESTE GGHGMSSWGR
MQALLAGATR RESRTEATEG QSPMGMHSLG AWWQERRFPF LFPPPQIPLS LPPPVRLPRI
PMLERWRLRW HDMSHLRRLV EVDDEDVETF PELEWDAQVR CSSELHADEQ AAIDKRRYLM
SSEGTNALAH FLQLPEGEYV HPDDVPLIAI GGSGGGYRAM FGYSGFLKEA ENTGLWQCTT
WCSAVSGSCW TLAAYYTIAQ CSTDVLIAHL LAMAHEEAHP MSLQAMDRIA RSSRGIYYLL
GPLLRKSRNK KLHCRIMDFY ATLVLSYQFL PRPLALFGTD YSYNGPRTNQ EPSLHEHSLW
AKYEPSEGLS RKSFQWSKVW ERTRVNEGLQ PIPILTGVRR VWRPYPAGDA PVQGPSHDGP
PLVGSGYDWY EISPLELGCR SIGAWIPTWA YGRTFENGRS THRAPEQMLT AIVGQCTGAP
AGPLTAYITT MLASIPQGTV MSTLLSWVND FVKMKQWEKR WGNPIRAADE PNPFYGRGMD
DVVINMDSAT PSVPPPPPAV TRPASPLPPP PPPTDDEARP ADPINTFFTQ LPRLPEFALE
HRLRPRRGSD ASASTSLLEN DPETFMAPME DLDVVHDDEE VGGNTHTRQW KWEHTRRLRL
MDSGLSNNLP NHVLAREERQ ADVIISFDAS SDVKTGAALE RLHEFGREFH IDIRPRPVGD
EPDVEISSTD GPETTVGQRP SLSPSAMQRD LESEAERMRL QYEHKYAQRL DGWRQKNGPA
EGREPDINFV YCPLLPNAAQ PGFDPTTAHY STSYNLIWTA DQVRALLRTA MANVEEGSRS
VRVIRDAVRE AYERKKKARL AREAGVPSVT VTDTGHVPHR RSSPTPADPD PPMGPRGVAG
PVPGEHMDDA PADDSELKSP RAPTPAPAPD KDNSPAGPDS VCATAPLGAS PLAMLAPAVT
AA
//