GenomeNet

Database: UniProt
Entry: M5GBA8_DACPD
LinkDB: M5GBA8_DACPD
Original site: M5GBA8_DACPD 
ID   M5GBA8_DACPD            Unreviewed;      2415 AA.
AC   M5GBA8;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 59.
DE   RecName: Full=Serine/threonine-protein kinase ATR {ECO:0000256|ARBA:ARBA00024420};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   ORFNames=DACRYDRAFT_112961 {ECO:0000313|EMBL:EJU06214.1};
OS   Dacryopinax primogenitus (strain DJM 731) (Brown rot fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Dacrymycetes;
OC   Dacrymycetales; Dacrymycetaceae; Dacryopinax.
OX   NCBI_TaxID=1858805 {ECO:0000313|EMBL:EJU06214.1, ECO:0000313|Proteomes:UP000030653};
RN   [1] {ECO:0000313|EMBL:EJU06214.1, ECO:0000313|Proteomes:UP000030653}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DJM-731 SS1 {ECO:0000313|EMBL:EJU06214.1,
RC   ECO:0000313|Proteomes:UP000030653};
RX   PubMed=22745431; DOI=10.1126/science.1221748;
RA   Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA   Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA   Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA   Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA   Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA   Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA   Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA   Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA   Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA   Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA   Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA   Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA   Hibbett D.S.;
RT   "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT   31 fungal genomes.";
RL   Science 336:1715-1719(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC       {ECO:0000256|ARBA:ARBA00010769}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JH795855; EJU06214.1; -; Genomic_DNA.
DR   STRING; 1858805.M5GBA8; -.
DR   HOGENOM; CLU_000178_2_5_1; -.
DR   OMA; SMYIGWC; -.
DR   OrthoDB; 8448at2759; -.
DR   Proteomes; UP000030653; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00892; PIKKc_ATR; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003152; FATC_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR003151; PIK-rel_kinase_FAT.
DR   InterPro; IPR014009; PIK_FAT.
DR   InterPro; IPR012993; UME.
DR   PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR   PANTHER; PTHR11139:SF69; SERINE/THREONINE-PROTEIN KINASE ATR; 1.
DR   Pfam; PF02259; FAT; 1.
DR   Pfam; PF02260; FATC; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF08064; UME; 1.
DR   SMART; SM01343; FATC; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SMART; SM00802; UME; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51189; FAT; 1.
DR   PROSITE; PS51190; FATC; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030653};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1389..1950
FT                   /note="FAT"
FT                   /evidence="ECO:0000259|PROSITE:PS51189"
FT   DOMAIN          2058..2363
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
FT   DOMAIN          2383..2415
FT                   /note="FATC"
FT                   /evidence="ECO:0000259|PROSITE:PS51190"
FT   REGION          2326..2352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2415 AA;  270025 MW;  3ACBF5AD03E45FA8 CRC64;
     MSTEDVNDYF TNLVSSLESD LAQPPLAGDA LVEFSNDDIT KFRTYALQLS AFLILDVSVW
     EDDSFKLAKI ALKYLHRTAG RIPAVLQKED DAEPLHLLVF VRLVTFSVHI FNWSYSSAQE
     ERQDAARNLG EVAVGIAAHV LCTLPGSMSR RAMEMGLEWS ELRRCLSLCA TYVNDLLNGR
     KNETYPLQMA FDVVQTDPYV LGVKNAPQSA VIILSGTHEA DIAAVSLIDI FVGVLHHSSD
     ASGLLAGFEV QTHDLALLAW ERIRRFPAPG SKGAARSTAL TCRLLQLSHR ILQDRVAAPL
     PLSMGDVCSH IERLTGRRLL DGYSPTLEEL DHNLGIVWEV LPTQYISHPT HAIDVCWRTD
     WSDVQKTEGL RSALYSYLLR ALPFCTAVDL SRLKGSLPEQ DSIALLARLR AAIEVKLQAS
     LSPSGTLSSV KKRKRDESSV GVETLAFLKV FDMGEFAIND FDEEHRVVLV DNVSAMFTKP
     LETSPDQRYA LAEAVAWLPC FLCHDIHSCI PTSGTENAAS SFLSLYVHAC LRLLAGKTED
     VPSRVWTKLL HGMRKAVRHS NIDTLSYSDQ ELFGLVKRAL ERAERSVRIA AGNVIAVVLA
     RHMEVDSFVL PKSNVWISVL IDIANGHGKP SIRETALVGL GSVGKVVSEA LIERILTCLI
     SHLADQNTLL RALAYTQLQA IVQAKSTTAY MLLMPHMSHV SVILVENLPV APNMLSEACQ
     FMGRSPTDFL SLTLHHTLPP LFAAGRKDVL QILARDLGKS IPQLAMGHES RVLAQIFLCP
     TEVQTDAGIE FLRGVISEAA KGAPIDLTGM VKGWIVELVS ELVIVLGDHE AKKSKMAIEA
     LKKVEKLLAT PAKGQRRAPT SDLSSFLKSY MLGIISRLND MLHELHGRKP DSFKCQVVRG
     IGSLIELVGP SVSSISPQIM ATLQGALPKE ALRESVLATW RTFITRLSPD DIGPYIGQTS
     AAFVTEWANF SNVERNLAYH TLDHIIEHGH QFPDHIKDVV SLQGIPDLRD LEQRLVQAQA
     EWDIQAHLHK LLHRTMNENS VVGLRALEEL KTFMLANAGL ISSLSSGDTF DPVIGLMVNA
     LLKASTRDGD SNEATRHAAY ECFGILGAMD PDRFEFSFPD ATIVMLRNFS DEDENIKFVL
     YLLQDLLVGA YRSTSDTKYQ SHLAFAIQEL LKICHFGPDL VISGAQSAIS GPIRGRWNSL
     PKYVLETVTP LLEGRFSLEN RSSDPQIRHP VYPNAPTYRE WIQVWTTHLI SRISAPEAKK
     IFAVFRSAVR NQDVGVAHRL LPHIVLNILL TGHDSDRDRV REEIISVLDD QVHPKLGVAA
     DRRMLCAQTI FSLMDHISRW IRLLRQDTSQ RRAESTRQRH GGHVTAVGHE ADEQLACVES
     LLSSIDPELM ARAALNCKYY ARSLLSFEQR IVALKENEKS SRDLQPYYEC LHQIYAELDE
     PDGMAGISTM VLSPSLEHQI REHEAVGNWT SAQSCWEVKL QSAPDDLASH IGLLRCLRNL
     GHYDTLRTHV KGVLSRIPDW TSALAGFQIE GAWIVGDWLD VKALSETACD SSELYVARLL
     LAIQMDDQPG ILSALSSARE YLGDHILSAG RQSYRGSYDV VIGLHVLQEL DMICITGEHS
     RSATLRSALG MADLSTRLAK RFDSILPTFR AREPIQSMRR TAFALKKTTQ PSLAVEIGKS
     WLTTARIARK AGYLQTAYSA TLQAQKYNAP FAFIQTSKLL RVNGEPVRAL QDLENAMEIY
     KNVSTGPPNE RISTADPETT TLAKAFSLQA RWMVEADRFT VTEIANKFSE ASKQAQRLES
     PYFHVGHFWD ETYTQFSADD KLKNSHFPFN TCKAYGKALS YGSKYIYQTM PRMLSLWLDL
     ADQDRSNAMG RLGESTQQIV LSTREKITEM IDKIHRRLPA WQWLTAFPQL ISRIIHPSSS
     VFQVLLKIMA GVLVTYPQQA LWLLTSASKS KREERAQRCK AVYSRAQAAP GPSRDHVGKL
     IAESIKMTTE LLNLADYNLG DNVYTMSISR QCRELRKITP SHLILPLQES MTVTLPPASA
     DQDQHKPFPH QAPIIHEFLD EVEVMKSLAK PRKLTIKAND GRTYWFLCKP KDDLRKDARL
     MDFNSMINKL LKKDSESRRR KLHIRTYGVI PLNEECGLLE WVPNTTGLRH ILAKSYEARK
     MKIYNNDIAT MLDKERYNGK PGIMFEKQLL PMFPPVFHEW FLAMFPEPTA WLNSRLSYGR
     TAAVMSMVGY VLGLGDRHGE NILFDSTNGD AVHVDFNCLF EKGTTLEVPE RVPFRLTQNM
     VDGLGVTGVE GVFRIACELT MGILRNHKDS LMSVLEAFVH DPLSEFEEEK RRQDQQAKQG
     RSRRGANVSA ATTADGRAMQ LRDYALKSLL PIESKLKGVY SSKQMTTRNQ VDVLIREATD
     PTNLGMMYVG WAAWL
//
DBGET integrated database retrieval system