ID M5WR03_PRUPE Unreviewed; 1093 AA.
AC M5WR03;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=GPI inositol-deacylase {ECO:0000256|RuleBase:RU365011};
DE EC=3.1.-.- {ECO:0000256|RuleBase:RU365011};
GN ORFNames=PRUPE_3G299200 {ECO:0000313|EMBL:ONI19810.1};
OS Prunus persica (Peach) (Amygdalus persica).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX NCBI_TaxID=3760 {ECO:0000313|EMBL:ONI19810.1, ECO:0000313|Proteomes:UP000006882};
RN [1] {ECO:0000313|EMBL:ONI19810.1, ECO:0000313|Proteomes:UP000006882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nemared {ECO:0000313|Proteomes:UP000006882};
RX PubMed=23525075; DOI=10.1038/ng.2586;
RA Verde I., Abbott A.G., Scalabrin S., Jung S., Shu S., Marroni F.,
RA Zhebentyayeva T., Dettori M.T., Grimwood J., Cattonaro F., Zuccolo A.,
RA Rossini L., Jenkins J., Vendramin E., Meisel L.A., Decroocq V.,
RA Sosinski B., Prochnik S., Mitros T., Policriti A., Cipriani G., Dondini L.,
RA Ficklin S., Goodstein D.M., Xuan P., Del Fabbro C., Aramini V., Copetti D.,
RA Gonzalez S., Horner D.S., Falchi R., Lucas S., Mica E., Maldonado J.,
RA Lazzari B., Bielenberg D., Pirona R., Miculan M., Barakat A., Testolin R.,
RA Stella A., Tartarini S., Tonutti P., Arus P., Orellana A., Wells C.,
RA Main D., Vizzotto G., Silva H., Salamini F., Schmutz J., Morgante M.,
RA Rokhsar D.S.;
RT "The high-quality draft genome of peach (Prunus persica) identifies unique
RT patterns of genetic diversity, domestication and genome evolution.";
RL Nat. Genet. 45:487-494(2013).
RN [2] {ECO:0000313|EMBL:ONI19810.1}
RP NUCLEOTIDE SEQUENCE.
RA Verde I., Jenkins J., Dondini L., Micali S., Pagliarani G., Vendramin E.,
RA Paris R., Aramini V., Gazza L., Rossini L., Bassi D., Troggio M., Shu S.,
RA Grimwood J.H., Tartarini S., Dettori M.T., Schmutz J.;
RT "WGS assembly of Prunus persica.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in inositol deacylation of GPI-anchored proteins
CC which plays important roles in the quality control and ER-associated
CC degradation of GPI-anchored proteins. {ECO:0000256|RuleBase:RU365011}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU365011}.
CC -!- SIMILARITY: Belongs to the GPI inositol-deacylase family.
CC {ECO:0000256|RuleBase:RU365011}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM007653; ONI19810.1; -; Genomic_DNA.
DR EMBL; CM007653; ONI19811.1; -; Genomic_DNA.
DR RefSeq; XP_007214910.1; XM_007214848.1.
DR AlphaFoldDB; M5WR03; -.
DR EnsemblPlants; ONI19810; ONI19810; PRUPE_3G299200.
DR EnsemblPlants; ONI19811; ONI19811; PRUPE_3G299200.
DR GeneID; 18782771; -.
DR Gramene; ONI19810; ONI19810; PRUPE_3G299200.
DR Gramene; ONI19811; ONI19811; PRUPE_3G299200.
DR KEGG; pper:18782771; -.
DR eggNOG; KOG3724; Eukaryota.
DR HOGENOM; CLU_009749_0_0_1; -.
DR OMA; LGHYFAH; -.
DR OrthoDB; 5477082at2759; -.
DR Proteomes; UP000006882; Chromosome g3.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR012908; PGAP1-like.
DR PANTHER; PTHR47346:SF1; GPI INOSITOL-DEACYLASE; 1.
DR PANTHER; PTHR47346; HYDROLASES, ACTING ON ESTER BOND; 1.
DR Pfam; PF07819; PGAP1; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU365011};
KW Hydrolase {ECO:0000256|RuleBase:RU365011};
KW Membrane {ECO:0000256|RuleBase:RU365011};
KW Protein transport {ECO:0000256|RuleBase:RU365011};
KW Reference proteome {ECO:0000313|Proteomes:UP000006882};
KW Transmembrane {ECO:0000256|RuleBase:RU365011};
KW Transmembrane helix {ECO:0000256|RuleBase:RU365011};
KW Transport {ECO:0000256|RuleBase:RU365011}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365011"
FT TRANSMEM 724..744
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365011"
FT TRANSMEM 773..791
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365011"
FT TRANSMEM 803..836
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365011"
FT TRANSMEM 873..896
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365011"
FT TRANSMEM 963..984
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365011"
FT TRANSMEM 1055..1072
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365011"
SQ SEQUENCE 1093 AA; 121957 MW; DC7247AAB03973E5 CRC64;
MQVQGFRAKS RVALLVVFVL CVCFAGFYDL LKPVSNGCTM TYMYPTYIPI PTTTAVSPAK
YGLYLYHEGW KKIDFKEHLK KLSGIPILFI PGNGGSYKQV RSLAAESDRA YQAGPLERTF
YQEASLTPEE GGEEIDVASF QLPNQYDSRL DWFTVDLEGE HSAMDSAILE EHAEYVVHSI
HRILDQYKES YETREREGAA TSGSLPKSVI LVGHSMGGFV ARAAVAHNRL RKSAVETILT
LSSPHQYPPV ALQPSLGHYF AHVNHEWRKG YEVQTTRAGH YVSDPVLSHV VVISISGSYN
DYQVRSKSES LDGIVPPSHG FMISSTGMRN VWLSMEHQAI LWCNQLVIQV SHTLLSLVDS
RTGQPFSDKR IRLAIFSKML RSGIPQSFNW MMQSHLSQQS LHVPSRDVKD KTGSLYTSAA
CPRNVHWSED GLERDLYIQT TTVTVLAMDG RRRWLDIQKL GSNGRSHFMF VTNLAPCSGV
RLHLWPEKRN STSELPVCIR ILEVTSKMVR IPSGPAPRQI EPGSQTEQAP PSAIFRLGPE
DMRGFRFLTI SVAPRPTISG RPPPAVSMAV GQFFNPEEGE REFSPWSLSS YSYKEISLKE
DHPLALNLSF TTSLGLLPVI FSLKTAGCGI KNSGLPDEQA DDIDNSKLCK LRCFPPVAFA
WDDTSGLHIF PNVYSETIVV DSSPALWSSP KSSEKTSVML LVDPHCSYRS AVAVSVTAAA
SRFLLLYNSQ IVGFALVVIF FALMQQTHAW DLDLPIPSIL MAVESNLRIP LPFLYLAMAP
ILLSFVLSFW ISQPFPSFAS FTVVSVICYL LANGFVIILI LISQFIFYAA AVVHIFIKTR
FQLWEKSANR FINLSSSFFS LKVLRVVKAN PLLVTALAAI TLVCLVHAAF GLFIILSLDA
LCCHSALCSH AQRHELFDCK KEGNDGSRHL PFKSDGDCCS NSPDSSKSFG EAQLEIFHHR
HGLFILHLAA ALMFVPSLVA WFQRIGMGHS FPWLVDSALC TGVILHGIFT SKPEFNSFLV
SLPGVRNLEV RLNFMYLVAG YYSYLSSLAL APFRVFYAMT AIGFTSFALM ILQRWNREKG
EAHFGSRKHS HRH
//
