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Database: UniProt
Entry: M5X6Q4_PRUPE
LinkDB: M5X6Q4_PRUPE
Original site: M5X6Q4_PRUPE 
ID   M5X6Q4_PRUPE            Unreviewed;       628 AA.
AC   M5X6Q4;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   23-MAY-2018, entry version 34.
DE   RecName: Full=Malic enzyme {ECO:0000256|RuleBase:RU003426};
GN   ORFNames=PRUPE_2G114100 {ECO:0000313|EMBL:ONI22207.1},
GN   PRUPE_ppa002842mg {ECO:0000313|EMBL:EMJ21737.1};
OS   Prunus persica (Peach) (Amygdalus persica).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; fabids; Rosales; Rosaceae; Amygdaloideae;
OC   Amygdaleae; Prunus.
OX   NCBI_TaxID=3760 {ECO:0000313|EMBL:EMJ21737.1};
RN   [1] {ECO:0000313|EMBL:ONI22207.1, ECO:0000313|Proteomes:UP000006882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nemared {ECO:0000313|Proteomes:UP000006882};
RX   PubMed=23525075; DOI=10.1038/ng.2586;
RA   Verde I., Abbott A.G., Scalabrin S., Jung S., Shu S., Marroni F.,
RA   Zhebentyayeva T., Dettori M.T., Grimwood J., Cattonaro F., Zuccolo A.,
RA   Rossini L., Jenkins J., Vendramin E., Meisel L.A., Decroocq V.,
RA   Sosinski B., Prochnik S., Mitros T., Policriti A., Cipriani G.,
RA   Dondini L., Ficklin S., Goodstein D.M., Xuan P., Del Fabbro C.,
RA   Aramini V., Copetti D., Gonzalez S., Horner D.S., Falchi R., Lucas S.,
RA   Mica E., Maldonado J., Lazzari B., Bielenberg D., Pirona R.,
RA   Miculan M., Barakat A., Testolin R., Stella A., Tartarini S.,
RA   Tonutti P., Arus P., Orellana A., Wells C., Main D., Vizzotto G.,
RA   Silva H., Salamini F., Schmutz J., Morgante M., Rokhsar D.S.;
RT   "The high-quality draft genome of peach (Prunus persica) identifies
RT   unique patterns of genetic diversity, domestication and genome
RT   evolution.";
RL   Nat. Genet. 45:487-494(2013).
RN   [2] {ECO:0000313|EMBL:EMJ21737.1}
RP   NUCLEOTIDE SEQUENCE.
RG   The International Peach Genome Initiative;
RA   Verde I., Abbott A.G., Salamini F., Schmutz J., Sosinski B.,
RA   Morgante M., Rokhsar D.S.;
RT   "The genome of Prunis persica.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ONI22207.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Verde I., Jenkins J., Dondini L., Micali S., Pagliarani G.,
RA   Vendramin E., Paris R., Aramini V., Gazza L., Rossini L., Bassi D.,
RA   Troggio M., Shu S., Grimwood J.H., Tartarini S., Dettori M.T.,
RA   Schmutz J.;
RT   "WGS assembly of Prunus persica.";
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Note=Divalent metal cations. Prefers magnesium or manganese.
CC       {ECO:0000256|PIRSR:PIRSR000106-3};
CC   -!- SIMILARITY: Belongs to the malic enzymes family.
CC       {ECO:0000256|RuleBase:RU003426}.
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DR   EMBL; KB638974; EMJ21737.1; -; Genomic_DNA.
DR   EMBL; CM007652; ONI22207.1; -; Genomic_DNA.
DR   RefSeq; XP_007220538.1; XM_007220476.1.
DR   EnsemblPlants; ONI22207; ONI22207; PRUPE_2G114100.
DR   GeneID; 18784996; -.
DR   Gramene; ONI22207; ONI22207; PRUPE_2G114100.
DR   KEGG; pper:18784996; -.
DR   KO; K00028; -.
DR   OMA; CLAAYMT; -.
DR   OrthoDB; EOG093606EM; -.
DR   Proteomes; UP000006882; Chromosome g2.
DR   GO; GO:0009507; C:chloroplast; IEA:EnsemblPlants.
DR   GO; GO:0005739; C:mitochondrion; IEA:EnsemblPlants.
DR   GO; GO:0005524; F:ATP binding; IEA:EnsemblPlants.
DR   GO; GO:0050897; F:cobalt ion binding; IEA:EnsemblPlants.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:EnsemblPlants.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:EnsemblPlants.
DR   GO; GO:0008270; F:zinc ion binding; IEA:EnsemblPlants.
DR   GO; GO:0006108; P:malate metabolic process; IEA:EnsemblPlants.
DR   GO; GO:0009651; P:response to salt stress; IEA:EnsemblPlants.
DR   Gene3D; 3.40.50.10380; -; 1.
DR   InterPro; IPR015884; Malic_enzyme_CS.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   PIRSF; PIRSF000106; ME; 1.
DR   PRINTS; PR00072; MALOXRDTASE.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00331; MALIC_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006882};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3,
KW   ECO:0000256|RuleBase:RU003426};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003426};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006882}.
FT   DOMAIN      125    305       malic. {ECO:0000259|SMART:SM01274}.
FT   DOMAIN      315    583       Malic_M. {ECO:0000259|SMART:SM00919}.
FT   COILED       84    104       {ECO:0000256|SAM:Coils}.
FT   ACT_SITE    148    148       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   ACT_SITE    219    219       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   METAL       290    290       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       291    291       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       314    314       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
SQ   SEQUENCE   628 AA;  70224 MW;  ADCCF180F4C3B604 CRC64;
     MSNFNSPIRL SSSLIKHLKY RVRMGSNPLL PHSRSFTTTE GHRPIIVHKR SLDILHDPWF
     NKGTSFSFTE RDRLDLRGLL PPNVMSTEQQ IERFMVDLKR LEEQARDGPS DPNALAKWRI
     LNRLHDRNET MYYKVLIANI EEYAPIVYTP TVGLVCQNYS GLFRRPRGMY FSAEDRGEMM
     SMVYNWPADQ VDMIVVTDGS RILGLGDLGV QGIGIAIGKL DLYVAAAGIN PQRVLPVMID
     VGTNNERLLK DPLYLGLQRH RLDGDEYLAV IDEFMEAVFT RWPHVIVQFE DFQSKWAFKL
     LQRYRNTYRM FNDDVQGTAG VAIAGLLGAV RAQGRPMIDF PKQKIVVAGA GSAGIGVLNA
     TRKTMARMLG NNEHAFQSAG RQFWVVDAKG LITEEREDLD PEARPFARNV KEIHRQGLRE
     GASLVEVVQE VKPDVLLGLS AVGGLFSKEV LEALRGSTST RPAIFAMSNP TTNAECTPEE
     AFSIVGDNVV FASGSPFKDV DLGNGHIGHC NQGNNMYLFP GIGLGTLLSG SRIISDGMLQ
     AAAECLAAYM TDEEVLKGVI YPSISSIRDI TKQVAAAVIK EAIEEDLAEG YREMDSRELR
     KLSQEEIKEY VLNSMWSPEY PTLVYRKE
//
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