ID M5X724_PRUPE Unreviewed; 942 AA.
AC M5X724;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Small RNA 2'-O-methyltransferase {ECO:0000256|ARBA:ARBA00021330};
DE EC=2.1.1.386 {ECO:0000256|ARBA:ARBA00035025};
DE AltName: Full=Rotamase {ECO:0000256|ARBA:ARBA00029569};
GN ORFNames=PRUPE_4G091400 {ECO:0000313|EMBL:ONI11183.1};
OS Prunus persica (Peach) (Amygdalus persica).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX NCBI_TaxID=3760 {ECO:0000313|EMBL:ONI11183.1, ECO:0000313|Proteomes:UP000006882};
RN [1] {ECO:0000313|EMBL:ONI11183.1, ECO:0000313|Proteomes:UP000006882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nemared {ECO:0000313|Proteomes:UP000006882};
RX PubMed=23525075; DOI=10.1038/ng.2586;
RA Verde I., Abbott A.G., Scalabrin S., Jung S., Shu S., Marroni F.,
RA Zhebentyayeva T., Dettori M.T., Grimwood J., Cattonaro F., Zuccolo A.,
RA Rossini L., Jenkins J., Vendramin E., Meisel L.A., Decroocq V.,
RA Sosinski B., Prochnik S., Mitros T., Policriti A., Cipriani G., Dondini L.,
RA Ficklin S., Goodstein D.M., Xuan P., Del Fabbro C., Aramini V., Copetti D.,
RA Gonzalez S., Horner D.S., Falchi R., Lucas S., Mica E., Maldonado J.,
RA Lazzari B., Bielenberg D., Pirona R., Miculan M., Barakat A., Testolin R.,
RA Stella A., Tartarini S., Tonutti P., Arus P., Orellana A., Wells C.,
RA Main D., Vizzotto G., Silva H., Salamini F., Schmutz J., Morgante M.,
RA Rokhsar D.S.;
RT "The high-quality draft genome of peach (Prunus persica) identifies unique
RT patterns of genetic diversity, domestication and genome evolution.";
RL Nat. Genet. 45:487-494(2013).
RN [2] {ECO:0000313|EMBL:ONI11183.1}
RP NUCLEOTIDE SEQUENCE.
RA Verde I., Jenkins J., Dondini L., Micali S., Pagliarani G., Vendramin E.,
RA Paris R., Aramini V., Gazza L., Rossini L., Bassi D., Troggio M., Shu S.,
RA Grimwood J.H., Tartarini S., Dettori M.T., Schmutz J.;
RT "WGS assembly of Prunus persica.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-adenosyl-L-methionine + small RNA 3'-end nucleotide = H(+) +
CC S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide;
CC Xref=Rhea:RHEA:37887, Rhea:RHEA-COMP:10415, Rhea:RHEA-COMP:10416,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74896, ChEBI:CHEBI:74898; EC=2.1.1.386;
CC Evidence={ECO:0000256|ARBA:ARBA00034992};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. HEN1 family.
CC {ECO:0000256|ARBA:ARBA00009026}.
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DR EMBL; CM007654; ONI11183.1; -; Genomic_DNA.
DR EMBL; CM007654; ONI11184.1; -; Genomic_DNA.
DR EMBL; CM007654; ONI11185.1; -; Genomic_DNA.
DR EMBL; CM007654; ONI11186.1; -; Genomic_DNA.
DR EMBL; CM007654; ONI11187.1; -; Genomic_DNA.
DR RefSeq; XP_007213676.1; XM_007213614.1.
DR AlphaFoldDB; M5X724; -.
DR STRING; 3760.M5X724; -.
DR EnsemblPlants; ONI11183; ONI11183; PRUPE_4G091400.
DR EnsemblPlants; ONI11184; ONI11184; PRUPE_4G091400.
DR EnsemblPlants; ONI11185; ONI11185; PRUPE_4G091400.
DR EnsemblPlants; ONI11186; ONI11186; PRUPE_4G091400.
DR EnsemblPlants; ONI11187; ONI11187; PRUPE_4G091400.
DR GeneID; 18778317; -.
DR Gramene; ONI11183; ONI11183; PRUPE_4G091400.
DR Gramene; ONI11184; ONI11184; PRUPE_4G091400.
DR Gramene; ONI11185; ONI11185; PRUPE_4G091400.
DR Gramene; ONI11186; ONI11186; PRUPE_4G091400.
DR Gramene; ONI11187; ONI11187; PRUPE_4G091400.
DR KEGG; pper:18778317; -.
DR eggNOG; KOG1045; Eukaryota.
DR HOGENOM; CLU_001342_0_0_1; -.
DR OMA; ELLWEWP; -.
DR OrthoDB; 2735228at2759; -.
DR Proteomes; UP000006882; Chromosome g4.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008171; F:O-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IBA:GO_Central.
DR GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR GO; GO:0030422; P:siRNA processing; IBA:GO_Central.
DR CDD; cd00048; DSRM_SF; 1.
DR Gene3D; 3.10.50.40; -; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR026610; Hen1.
DR InterPro; IPR040870; HEN1_dsRBD2.
DR InterPro; IPR040813; Hen1_Lam_C.
DR InterPro; IPR006630; La_HTH.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR046357; PPIase_dom_sf.
DR InterPro; IPR001179; PPIase_FKBP_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR21404; HEN1; 1.
DR PANTHER; PTHR21404:SF3; SMALL RNA 2'-O-METHYLTRANSFERASE; 1.
DR Pfam; PF17842; dsRBD2; 1.
DR Pfam; PF00035; dsrm; 1.
DR Pfam; PF00254; FKBP_C; 1.
DR Pfam; PF18441; Hen1_Lam_C; 1.
DR Pfam; PF21224; Hen1_LCD; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF54534; FKBP-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50961; HTH_LA; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000006882};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00332};
KW RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 88..199
FT /note="HTH La-type RNA-binding"
FT /evidence="ECO:0000259|PROSITE:PS50961"
SQ SEQUENCE 942 AA; 104169 MW; 7404BD07320C59CD CRC64;
MTTFTPKAIV HKRFGSSACY KVEEVHESTQ NGCPGLAIMQ KGPCLYRCTL QLPEVTVVSG
IFKKKKDAEQ SAAELALEKL GINPATKSPS LQEAWDALVA RVSFLFSDEF LSTLHPLSGH
FRAALQRDGD LSGQIPASVI AIFDATLCNM CKSLDPKVES NPFLVILYVV RAAARLSELI
STSEEELWFR RRNPYAPETV ESSSIQQLGS TEIFSIEAIN VPSSLEKTVE RVILNVSSSG
YFLDVIAKQL GLSKTSDVLI SRPMGKASSE TRLYFAAPKQ YLLDMSSDLL NAKEACNSEG
SLNARASYLS GQDIYGDAIL ASIGYTWRSK DLFYEDVTLQ SYHRMVIGKT PGGIYKLSRG
AILAAELPLA FTTNAKWKGS FPREMLCTFC RQHRLEPVFS PQSTLEESSE SPKSHKKLKV
TDLPVKEAQY ENGCVVAAGV KDSVESGGSF RCEVKIVSKF QDFILECSPK DSFKKQSDSI
QNVSLKVLLW LNAYFRDPTV PLERLNASAD GLNIRFDPQN FIKVFMLCQH IHNVRHNETE
EGKSVCSNSV NVSYALPGRE FRSLNIEGPD SGVTPSNGSL SSVSYSVSLV TEGEHMKELL
ESSDDFEFEI ASGSVIPHLE TVVMQMTVGQ SAFFSMDLPH QELILAAADD SARMLPLLSS
KTCFLEYTIT LLQVTEPLED RMEQALFSPP LSKQRVEYAV QSIKESCATT LVDFGCGSGS
LLDSLLNYPT SLEKIAGVDI SQKSLTRAAK ILHSKLDASM SAINSAVLYD GSITAFDSRL
SGFDIGTCLE VIEHMEEDQA SEFGNVVLSL FRPRVLIVST PNYEYNVILQ KSNLSSQEDD
PEDKNQAQSC KFRNHDHKFE WTREQFNCWA TELATRHNYS VEFSGVGGSG DTEPGFASQI
AVFIRGPVRQ EDVLPEVSDM EHPYKVIWEW SSNDSSRSAV TN
//