ID M5X7R9_PRUPE Unreviewed; 1086 AA.
AC M5X7R9;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Bifunctional fucokinase/fucose pyrophosphorylase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PRUPE_2G192700 {ECO:0000313|EMBL:ONI23519.1};
OS Prunus persica (Peach) (Amygdalus persica).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX NCBI_TaxID=3760 {ECO:0000313|EMBL:ONI23519.1, ECO:0000313|Proteomes:UP000006882};
RN [1] {ECO:0000313|EMBL:ONI23519.1, ECO:0000313|Proteomes:UP000006882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nemared {ECO:0000313|Proteomes:UP000006882};
RX PubMed=23525075; DOI=10.1038/ng.2586;
RA Verde I., Abbott A.G., Scalabrin S., Jung S., Shu S., Marroni F.,
RA Zhebentyayeva T., Dettori M.T., Grimwood J., Cattonaro F., Zuccolo A.,
RA Rossini L., Jenkins J., Vendramin E., Meisel L.A., Decroocq V.,
RA Sosinski B., Prochnik S., Mitros T., Policriti A., Cipriani G., Dondini L.,
RA Ficklin S., Goodstein D.M., Xuan P., Del Fabbro C., Aramini V., Copetti D.,
RA Gonzalez S., Horner D.S., Falchi R., Lucas S., Mica E., Maldonado J.,
RA Lazzari B., Bielenberg D., Pirona R., Miculan M., Barakat A., Testolin R.,
RA Stella A., Tartarini S., Tonutti P., Arus P., Orellana A., Wells C.,
RA Main D., Vizzotto G., Silva H., Salamini F., Schmutz J., Morgante M.,
RA Rokhsar D.S.;
RT "The high-quality draft genome of peach (Prunus persica) identifies unique
RT patterns of genetic diversity, domestication and genome evolution.";
RL Nat. Genet. 45:487-494(2013).
CC -!- SIMILARITY: Belongs to the GHMP kinase family.
CC {ECO:0000256|ARBA:ARBA00038121}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM007652; ONI23519.1; -; Genomic_DNA.
DR RefSeq; XP_007220913.1; XM_007220851.1.
DR AlphaFoldDB; M5X7R9; -.
DR STRING; 3760.M5X7R9; -.
DR EnsemblPlants; ONI23519; ONI23519; PRUPE_2G192700.
DR GeneID; 18785393; -.
DR Gramene; ONI23519; ONI23519; PRUPE_2G192700.
DR KEGG; pper:18785393; -.
DR eggNOG; KOG4644; Eukaryota.
DR HOGENOM; CLU_006983_1_1_1; -.
DR OMA; QKMFSYC; -.
DR OrthoDB; 5800at2759; -.
DR Proteomes; UP000006882; Chromosome g2.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0050201; F:fucokinase activity; IBA:GO_Central.
DR GO; GO:0042352; P:GDP-L-fucose salvage; IBA:GO_Central.
DR Gene3D; 3.30.230.120; -; 1.
DR InterPro; IPR012887; Fucokinase.
DR InterPro; IPR013750; GHMP_kinase_C_dom.
DR InterPro; IPR036554; GHMP_kinase_C_sf.
DR InterPro; IPR006204; GHMP_kinase_N_dom.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR PANTHER; PTHR32463; L-FUCOSE KINASE; 1.
DR PANTHER; PTHR32463:SF0; L-FUCOSE KINASE; 1.
DR Pfam; PF07959; Fucokinase; 1.
DR Pfam; PF08544; GHMP_kinases_C; 1.
DR Pfam; PF00288; GHMP_kinases_N; 1.
DR PRINTS; PR00959; MEVGALKINASE.
DR SUPFAM; SSF55060; GHMP Kinase, C-terminal domain; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006882};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 154..552
FT /note="L-fucokinase"
FT /evidence="ECO:0000259|Pfam:PF07959"
FT DOMAIN 848..912
FT /note="GHMP kinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00288"
FT DOMAIN 992..1065
FT /note="GHMP kinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08544"
SQ SEQUENCE 1086 AA; 119091 MW; 6F35F30B8713BA9A CRC64;
METSSLSRSR QKADVAGVLR KSWYHLRLSV RHPTRVPTWD AIVLTAASPE QAQLYEWQLT
RAKRVGRIAA STITLAVPDP DGQRIGSGAA TVHAIHALAK HYRTVGPHSE VATTSNGSSG
FSESHKNPED EVDDDDLSQM VSFIAKRHIL LLHAGGDSKR VPWANPMGKV FLPLPYLAAD
DPDGPVPLLF DHILAIASCA RQAFKNEGGI FTMTGDVLPC FDASNMVLPE DTSCIITVPI
TLDIASNHGV VVASKSRNVE RSYTVSLVDN LLQKPSLEEL VKNNAILDDG RTLLDTGIIA
VRGKGWEELV ALACSCQPMI SELLKSGKEM SLYEDLVAAW VPAKHDWLCL RPSGEELVSR
LGKQKMFSYC AYDLSFLHFG TSSEVLDHLS GASLVLVSRR HQCSIPATNL SDIAASAVLL
SSKIAPAVSI GEDSLIYDST ISSGIQIGSL SIVVGINVPS VNSTAAENSF RFILPDRHCL
WEVPLVGRTG RVIVYCGLHD NPKNSVSKDG TFCGKPWRKV LHDLGIQEND LWSSTGTHEK
CLWNAKIFPI LSYFEMLNLA SWLMGLSDQN SKHFLSLWRS SPRVSLEELH RSIDFSKMCQ
GSIDHQADLA AGIAKACIKY GMLGCNLYQL CEEILQKEDL GVKICEDFLG LCPGLLEQNS
KILPKSRAYQ LQVDLLRACR NETTACKLDH KVWDAVAEET ASAVKYGFKE YLFEAPSDIP
TPVYKNNDFD GSADHSFHPR RVKVELPVRV DFVGGWSDTP PWSLERAGSV LNMAISLEGS
LPIGAIIETA ETIGVFIKDD AGNEIHIEDL TSIATPFDGN DPFRLVKSAL LVTGIIHGSV
VASMGLQIRT WAHVPRGSGL GTSSILAAAV VKGLLQITDG DESNENVARL VLVLEQLMGT
GGGWQDQIGG LYPGIKFNAS FPGIPLRLQV VPLLASPELI SELQQRLLVV FTGQVRLAHQ
VLQKVVIRYL RRDNLLVSSI KRLAELAKIG REALMNCDID DLGEIMLEAW RLHQELDPYC
SNEFVDRLFG FAHPYCCGYK LVGAGGGGFS LLLAKDARHA KELRHLLEED SSFDVKIYNW
NIFLDN
//
