ID   M6VQC7_9LEPT            Unreviewed;       327 AA.
AC   M6VQC7;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=3-beta hydroxysteroid dehydrogenase/isomerase family protein {ECO:0000313|EMBL:EMO58970.1};
GN   ORFNames=LEP1GSC161_1967 {ECO:0000313|EMBL:EMO58970.1};
OS   Leptospira santarosai str. CBC1416.
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=1193059 {ECO:0000313|EMBL:EMO58970.1, ECO:0000313|Proteomes:UP000012149};
RN   [1] {ECO:0000313|EMBL:EMO58970.1, ECO:0000313|Proteomes:UP000012149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBC1416 {ECO:0000313|EMBL:EMO58970.1,
RC   ECO:0000313|Proteomes:UP000012149};
RA   Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA   Sanka R., DePew J., Purushe J., Matthias M.A., Vinetz J.M., Sutton G.G.,
RA   Nierman W.C., Fouts D.E.;
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMO58970.1}.
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DR   EMBL; AKWE02000054; EMO58970.1; -; Genomic_DNA.
DR   AlphaFoldDB; M6VQC7; -.
DR   Proteomes; UP000012149; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48079; PROTEIN YEEZ; 1.
DR   PANTHER; PTHR48079:SF6; PROTEIN YEEZ; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Isomerase {ECO:0000313|EMBL:EMO58970.1}.
FT   DOMAIN          9..252
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   327 AA;  35947 MW;  9753FC0E6E910C2E CRC64;
     MGRRMNIFIT GASGFVGEAA TRILSKKHSV KAMSRSAKAD SVISAAGGKP VRCELNSVDS
     NSLKGTDVVI HSAAYVEQWG PFSDFWKVNV DGTAQLLEAS HKAGVKRFIF IGTEAALFYG
     QPMLDIDESY PYPENSPFPY SKTKAEAEKL VLKANSSEMQ TLSIRPRLIW GPGDKTVLPV
     LLKMIADGNF SWIDGGKALT STTHIYNLIH SIELALTKGQ GGKAYFVTDD EVFNFRNFLE
     SLLATQKVTA PNRSIPGWLA RFLGRVLEGI WKLLRIKNEP PLTRFSASIM SRDCTIKIDN
     AKKDLGYSPL LTVRQGLAEM PVLKSAD
//