ID M6ZVX5_9ACTN Unreviewed; 407 AA.
AC M6ZVX5;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 2.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Probable acetyl-CoA acetyltransferase {ECO:0000256|ARBA:ARBA00040529};
DE EC=2.3.1.9 {ECO:0000256|ARBA:ARBA00012705};
GN ORFNames=ISGA_4903 {ECO:0000313|EMBL:EMP10206.2};
OS Gordonia sp. NB41Y.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=875808 {ECO:0000313|EMBL:EMP10206.2, ECO:0000313|Proteomes:UP000011989};
RN [1] {ECO:0000313|EMBL:EMP10206.2, ECO:0000313|Proteomes:UP000011989}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NB4-1Y {ECO:0000313|EMBL:EMP10206.2,
RC ECO:0000313|Proteomes:UP000011989};
RX PubMed=23744905; DOI=10.1099/mic.0.068932-0;
RA Van Hamme J.D., Bottos E.M., Bilbey N.J., Brewer S.E.;
RT "Genomic and proteomic characterization of Gordonia sp. NB4-1Y in relation
RT to 6 : 2 fluorotelomer sulfonate biodegradation.";
RL Microbiology 159:1618-1628(2013).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMP10206.2}.
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DR EMBL; APHK02000088; EMP10206.2; -; Genomic_DNA.
DR RefSeq; WP_053778178.1; NZ_CP132196.1.
DR AlphaFoldDB; M6ZVX5; -.
DR STRING; 1241906.ISGA_4903; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000011989; Unassembled WGS sequence.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR18919:SF153; TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:EMP10206.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000011989};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:EMP10206.2}.
FT DOMAIN 7..273
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 282..404
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 91
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 362
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 392
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 407 AA; 42087 MW; 386ACDE6B0D64DC1 CRC64;
MATGTDIVIC SPLRTPVGRM GGVLASQTVT DLATTLLREL ASRTGLGEGD VDDVILGQGY
ANGESPAIGR MAALDAGLGV GVPGMQVDRR CGSGLQAVLS GAAQVASGGA SLVIAGGAES
MSNVEHYALG LRTGIRQGGV ELMDRLDRGR LTAGGSSHPI PGGMIETAEN LRARYHLGRA
EQDEFAVESH RRAIAAQDAG KFDDEIVPVT IPGRRGKPDV VVERDEHPRA DASVEGLSKL
RAIRAKIDPD STVTAGNASG QNDGAAMCVV TTRAEAERRG LTPLLALKSW AVTGCAPEEM
GIGPVGATAA ALQRADLTLD EIDLIELNEA FAAQVLAVLA EWKIDAGDER LNPNGSGISL
GHPIGATGAR ILATAAHEAR RRESRYVLET MCIGGGQGLA AIFEAIR
//
