ID M7AN82_CHEMY Unreviewed; 636 AA.
AC M7AN82;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Mitogen-activated protein kinase kinase kinase 2 {ECO:0000313|EMBL:EMP26691.1};
DE Flags: Fragment;
GN ORFNames=UY3_16229 {ECO:0000313|EMBL:EMP26691.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP26691.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
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DR EMBL; KB576444; EMP26691.1; -; Genomic_DNA.
DR AlphaFoldDB; M7AN82; -.
DR STRING; 8469.M7AN82; -.
DR eggNOG; KOG0198; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06405; PB1_Mekk2_3; 1.
DR CDD; cd06652; STKc_MEKK2; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR034879; PB1_MEKK2/3.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR PANTHER; PTHR48016; MAP KINASE KINASE KINASE SSK2-RELATED-RELATED; 1.
DR PANTHER; PTHR48016:SF50; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EMP26691.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EMP26691.1}.
FT DOMAIN 41..120
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
FT DOMAIN 374..634
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 19..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 403
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EMP26691.1"
FT NON_TER 636
FT /evidence="ECO:0000313|EMBL:EMP26691.1"
SQ SEQUENCE 636 AA; 71482 MW; 24E27C84D4845CB7 CRC64;
EQQALNSIMQ DLAVLHKASR PALPVQETGK PKSSSPKKQN DVRVKFEHRG EKRILQFPRP
VKLEDLASKA KVAFGQPMDL HYSNNELVIP LTTQDDLDKA VELLDRSVHM KSLKILLVIH
GNSQAPVLSN MEPLPSLEDL DNTVFGVAER KNRLSVIVQE NCSPILPFFF LLKGSNTRDR
SSPPPGYIPD ELHQVVRNGS FTSINSEGEF IPESMDQMLD PLSLSSPENS GSGSCPSLDS
PLDGDSYPKS RMPRAQSYPD NHQEFSDYDI PIFEKFGKGG TYPRRYHISY HHQDYNDGRK
TFPRARRTQG NSFRSPVSFS PTDHSLSTSS GSSTFTPEYE ENRMRRRGSD IDNPTLSVMD
ISPPSRSPRA PTNWRLGKLL GQGAFGRVYL CYDADTGREL AVKQVQFDPD SPETSKEVNA
LECEIQLLKN LLHERIVQYY GCLRDPPERT LSIFMEYMPG GSIKDQLKAY GALTENVTRK
YTRQILEGVY YLHSNMIVHR DIKGANILRD SAGNVKLGDF GASKRLQTIC LSGTGMKSVM
GTPYWMSPEV ISGEGYGRKA DIWSVGCTVV EMLTEKPPWA EYEAMAAIFK IATQPTNPQL
PPHVSDHGRD FLKRIFIEAK LRPSADELLR HTFAHY
//
