ID M7ASD7_CHEMY Unreviewed; 688 AA.
AC M7ASD7;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Engulfment and cell motility protein 2 {ECO:0000313|EMBL:EMP28276.1};
GN ORFNames=UY3_14610 {ECO:0000313|EMBL:EMP28276.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP28276.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC phagocytosis of apoptotic cells and cell motility. Acts in association
CC with DOCK1 and CRK. Was initially proposed to be required in complex
CC with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC nucleotide exchange factor (GEF) activity of DOCK1.
CC {ECO:0000256|ARBA:ARBA00024863}.
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DR EMBL; KB564564; EMP28276.1; -; Genomic_DNA.
DR AlphaFoldDB; M7ASD7; -.
DR STRING; 8469.M7ASD7; -.
DR eggNOG; KOG2999; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR CDD; cd13359; PH_ELMO1_CED-12; 1.
DR Gene3D; 6.10.250.810; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024574; ELMO_ARM.
DR InterPro; IPR006816; ELMO_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR PANTHER; PTHR12771:SF8; ENGULFMENT AND CELL MOTILITY PROTEIN 2; 1.
DR Pfam; PF11841; ELMO_ARM; 1.
DR Pfam; PF04727; ELMO_CED12; 2.
DR Pfam; PF16457; PH_12; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 115..272
FT /note="ELMO armadillo-like helical"
FT /evidence="ECO:0000259|Pfam:PF11841"
FT DOMAIN 295..392
FT /note="ELMO"
FT /evidence="ECO:0000259|Pfam:PF04727"
FT DOMAIN 400..442
FT /note="ELMO"
FT /evidence="ECO:0000259|Pfam:PF04727"
FT DOMAIN 509..635
FT /note="PH"
FT /evidence="ECO:0000259|Pfam:PF16457"
SQ SEQUENCE 688 AA; 78957 MW; 3618FF31A92E2CD9 CRC64;
MPPPVDIVKV AVEWPGANAQ LLEIDQKRPL ASVIKEVCDG WSLPNPEYYT LRYADGPQLY
ITEQTRCDIK NGTILQLAVS PSRAARQLME RTQSHSMEAR LDAMKELAKL SADVTFATEF
INMEGITVLT RLVESGTKLL SHYSEMLAFT LTAFLELMDH GIVSWDMVSI TFIKQIAGYV
SQPMVDVSIL QRSLAILESM VLNSQTLYQK IAEEITVGQL ISHLQVSNQE IQTYAIALIN
ALFLKAPEDK RQEMANAFAQ KHLRSIILNH VIRGNRPIKT EMAHQLYVLQ VLTFNLLEER
MMTKMDPNDQ AQRDVIFELR RIAFDAESDG NTIPGGGTEK RKAMYTKDYK MLGFTNHINP
AMDFTQTPPG MLALDNMLYL AKCHQDTYIR VGELPNEGRN DYHPMFFTHD RAFEELFAIC
IQLLNKTWKE MRATAEDFNK VMQVVREQIT RALPSKPNSL DQFKSKLRSL SYSEILRLRQ
SERMSQDDFQ SPPIVELREK IQPEILELIK QQRLNRLCEG SSFRKIGNRR RQERFWYCRL
ALNHKVLHYG DLEDNAQGEV TFESLQEKIP VADIKAIVTG KDCPHMKEKS ALKQNKEVLE
LAFSILYDPD ETLNFIAPNK YEYCIWIDGL NALLGKDMSS ELTKSDLDTL LSMEMKLRLL
DLENIQIPEA PPPIPKEPSS YDFVYHYG
//
