ID M7ATD8_CHEMY Unreviewed; 778 AA.
AC M7ATD8;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Histone-lysine N-methyltransferase SETDB1 {ECO:0000313|EMBL:EMP27949.1};
GN ORFNames=UY3_14926 {ECO:0000313|EMBL:EMP27949.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP27949.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KB565896; EMP27949.1; -; Genomic_DNA.
DR AlphaFoldDB; M7ATD8; -.
DR STRING; 8469.M7ATD8; -.
DR eggNOG; KOG1141; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd01395; HMT_MBD; 1.
DR CDD; cd10517; SET_SETDB1; 1.
DR Gene3D; 2.170.270.10; SET domain; 2.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR047232; SETDB1/2-like_MBD.
DR PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR PANTHER; PTHR46024:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Methyltransferase {ECO:0000313|EMBL:EMP27949.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Transferase {ECO:0000313|EMBL:EMP27949.1}.
FT DOMAIN 203..276
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 279..743
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..386
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..527
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 778 AA; 86299 MW; 33C9B9979BBF0DB2 CRC64;
MGKAAVNQQY RGSYSSGQPG SSAVQPFHGM MDRVPNEPSY RAPMEKLFYL PHVCSYTCLS
RVRPIRSDQY RSKNPLLIPL LYDFRRMTAR RRVNRKMGFH VIYKTPCGLC LRTMQEIERY
IFETDCDFLF LEMFCLDPYV LVDRKFQPYK PFYYIADITK GKEDVPLSCV NEIDTTPPPQ
VAYSKERIPG KGVYINTGWE FLVGCDCKDG CRDKSKCACH QLTVQATGCT PGGQINPNSG
YQHKRLEECL PTGVYECNKR CKCNTNMCTN RLVQHGLQVR LQLFKTQNKG WGIRCLDDIA
KGSFVCIYAG KILTDDFADK EGLEMGDEYF ANLDHIESVE NFKEGYESDA KCSSDSSGVD
LKDEEEENTG TEEQDESNED SSDDNFCKDE DFSTSSVWRS YATRRQTRGQ KENGLSETAS
KDSGLTRQIS HDEVAMTAAC KLPVSEETSK NKVASWLSSN SMSDSFQDND SASSFKMTEA
SEVKAGKVEV LGDREKPSTS GLGGKEAFGL DADSKMQKKE ESEEPNKLSL ASETGKVYGY
NPSPMKLEGI RRPPSKTIMH QSKRHLAPPQ QAADDVLTLS SSTDSEGENG QPAAGQAQGN
TNDSDDIQTI SSGSEEEDID DKKNSSSGLG PIKRQVAVKS TRGFALKSTH GIAIKSTNMA
SADKGENMLV RKNTRQFYDG EESCYIIDAK LEGNLGRYLN HSCSPNLFVQ NVFVDTHDLR
FPWVAFFASK ATAAPRGVLA VAGKQSRSIA AGYAALSPPT SLSHGLLPSK ACEMLLFR
//
