ID M7AU83_CHEMY Unreviewed; 1159 AA.
AC M7AU83;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Multidrug resistance protein 1 {ECO:0000313|EMBL:EMP26530.1};
DE Flags: Fragment;
GN ORFNames=UY3_16388 {ECO:0000313|EMBL:EMP26530.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP26530.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KB578553; EMP26530.1; -; Genomic_DNA.
DR AlphaFoldDB; M7AU83; -.
DR STRING; 8469.M7AU83; -.
DR eggNOG; KOG0055; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18558; ABC_6TM_Pgp_ABCB1; 1.
DR CDD; cd18578; ABC_6TM_Pgp_ABCB1_D2_like; 1.
DR CDD; cd03249; ABC_MTABC3_MDL1_MDL2; 2.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24222; ABC TRANSPORTER B FAMILY; 1.
DR PANTHER; PTHR24222:SF76; MYCOBACTIN IMPORT ATP-BINDING_PERMEASE PROTEIN IRTA; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 741..761
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 819..843
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 855..876
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..309
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 344..580
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 707..882
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 917..1155
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EMP26530.1"
SQ SEQUENCE 1159 AA; 127418 MW; 341500C9DF9B42A7 CRC64;
FRYADWLDKL LMVLGSALAI LHGAALPVMM IIFGDMTDSF VIPRNLSSGN ISFNPYEKLE
EQMSRYAYYY SGIGAGVLFA AYIQIAFWTL AAGRQIKKIR QQFFHSIMRQ EIGWFDVNDV
GELNTRLIDD VSKINEGIGD KIGMLFQSIA TFLTGFIVGF IKGWKLTLVI LAVSPVLGLS
AALWAKILSA FTDKELTAYA KAGAVAEEVL AAIRTVIAFG GQKKEIKRYH KNLEDAKNIG
IKKAITANVS MGIAFLLIYA SYALAFWYGT TLVLSDDYSI GKVLTVFFAI LIGAFSVGQT
APGMEAFANA RGAAYAIFNI IDNEPQIDSF SETGYKPDHI QGNLEFHNVY FNYPSRQDVK
VLKGLNLKVN CGQTVALVGS SGCGKSTTVQ LIQRFYDPEK GMITIDGHDI KTLNLRYLRE
IIGVVNQEPV LFATTIAENI RYGREDVTME EIKKAVKEAN AYDFIMKLPD KFETIVGERG
AQLSGGQKQR IAIARALVRN PKILLLDEAT SALDTESESV VQTALDKARE GRTTIVIAHR
LSTVRNADLI AAFEDGVITE QGTHRELMKT NGIYCKLVNM QTIGTEVQSE EAGTTTEVAL
KESTGNGLRR RLTRKSTKKS EIQDDSLDVK IVQPDENVPP VSFLKVMKLN KSEWPYFVVG
TFSAIINGAL QPAFAIIFSE IIGGFTFGKA GEILTMRLRF MAFKAMLRQA TGARLALITQ
NIANLGTGIV ISFVYGWQLT LLILAIVPII AIAGIIQMKI FSGHAKKDKE ELEAAGKIAT
EAIENIRTVV TLTQERKFEF MYGQNLQGPY RNSVKKAHIF GLSFGLTQAI IYFTYAGCFR
FGAYLVGNGD MEFKSVFLVF SAIVISAMTL GQTSSFTPDY AKAKLSAAHL FTLFERAPLI
DSYSDEGLKP DIFGGNVAFK EVTFNYPTRP DVQVLQGLNI KVEKGQTLAL VGSSGCGKST
VIQLLERFYD PLGGEMLLDG QKAKSLNIQW LRAHIGIVSQ EPILFDCSIA ENIAYGDNSR
EVSSEEIVNA ARAANIHSFI DSLPNKYNTC VGDKGTQLSG GQKQRIAIAR ALVRHPQILL
LDEATSALDT ESEKVVQEAL DKARQGRTCI VIAHRLSTVQ NADKIAVIQN GKVVEQGTHQ
QLLAERGIYY SLVNVQAGP
//
