ID M7AY60_CHEMY Unreviewed; 875 AA.
AC M7AY60;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Very low-density lipoprotein receptor {ECO:0000313|EMBL:EMP30461.1};
GN ORFNames=UY3_12463 {ECO:0000313|EMBL:EMP30461.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP30461.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KB549795; EMP30461.1; -; Genomic_DNA.
DR AlphaFoldDB; M7AY60; -.
DR STRING; 8469.M7AY60; -.
DR eggNOG; KOG1215; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 8.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 8.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF8; VERY LOW-DENSITY LIPOPROTEIN RECEPTOR; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM00192; LDLa; 8.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 8.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 8.
DR PROSITE; PS51120; LDLRB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:EMP30461.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EMP30461.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..875
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004079588"
FT TRANSMEM 781..803
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 350..390
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 440..485
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 486..528
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 529..572
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 573..617
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 842..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 32..44
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 39..57
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 51..66
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 71..83
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 78..96
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 133..148
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 153..165
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 160..178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 172..187
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 192..204
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 199..217
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 238..250
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 245..263
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 257..272
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 277..289
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 284..302
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 296..311
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 325..343
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 875 AA; 96172 MW; 86B676783E089927 CRC64;
MGTSSLRGLW LLAVLCWLLG ERGAVRGARA KCEESQFQCS NGRCITLLWK CDGDEDCSDG
SDESSCVKTT CTESDFVCNS GQCVPNRWQC DGDPDCEDGS DESPELCHMR TCRVNEISCG
PRSTQCIPLS WKCDGENDCD SGEDEENCGN ITCSPAEFTC SSGQCISKNF VCNGQDDCSD
GSDELDCTPP TCGAHEFQCK SSSCIPISWV CDDDADCSDQ SDESLEQCGR QPAHPVKCFP
SEVQCGSGEC IHKKWWCDGD SDCKDGSDET NCPSRTCRPD QFKCEDGNCI HGSRQCNGVR
DCLDGTDEVN CKNVNQCSGP GKFKCRSGEC IDISKVCNQQ QDCQDWSDEP LKECNIDECQ
NPGICSQICI NLKGGYKCEC SHGYQMDLAT GVCKAVGKEP CLIFTNRRDI RKIGLERKEY
LQLVEQLRNT IALDADIAEH KLFWADFSQK AIFSASLDSR DKVGKHLKII SNVHSPAAIA
VDWVYKNIYW TDSALKSISV ASLDGAKRKI LFNTDLREPA SIAVDPLSGF MYWSDWGEPA
KIEKAGMNGL GRQQLVTTEI QWPNGIALDL IKSRLYWLDS KLHMLSSVDL NGQDRRIVLK
SHEFLAHPLA LTIFEDRVYW IDGENEAVYG ANKFTGSELA TLVNNLNNAQ DIIVYHELVQ
PTGNRCKLAM LDFHTMNLCL AAIKSGKNWC EETTKNGGCE YLCLPAPQIN EHSPKYACTC
PNGYNLQDDG LRCKGAGTTV AYIETKDTST TEKPPTVGPV PGGHNFSSAV SEVSSAKGTS
AAWAILPLVL LALAAAAGGY FMWRNWQHKN MKSMNFDNPV YLKTTEEDLT IDIGRHSSSV
GHTYPANSHT NSAFIGSDPK PLSGKARARA RHGKP
//
