ID M7B1L0_CHEMY Unreviewed; 588 AA.
AC M7B1L0;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Regulator of G-protein signaling 14 {ECO:0000313|EMBL:EMP30934.1};
DE Flags: Fragment;
GN ORFNames=UY3_11921 {ECO:0000313|EMBL:EMP30934.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP30934.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
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DR EMBL; KB547574; EMP30934.1; -; Genomic_DNA.
DR AlphaFoldDB; M7B1L0; -.
DR STRING; 8469.M7B1L0; -.
DR eggNOG; KOG3589; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0001965; F:G-protein alpha-subunit binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd17137; RBD1_RGS14; 1.
DR CDD; cd08743; RGS_RGS14; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR046992; RBD1_RGS14.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR046995; RGS10/12/14-like.
DR InterPro; IPR037881; RGS14_RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45945:SF2; REGULATOR OF G-PROTEIN SIGNALING 14; 1.
DR PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00390; GoLoco; 1.
DR SMART; SM00455; RBD; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50877; GOLOCO; 1.
DR PROSITE; PS50898; RBD; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443}.
FT DOMAIN 43..160
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 292..363
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EMP30934.1"
SQ SEQUENCE 588 AA; 63604 MW; 9FB18F82D4886D1A CRC64;
LAVSDGELNS SGARGSSHSV HSLPGAQNAG CAAELPVASW AESFETLLQD RVAVTYFTEF
LKKEFSAENV YFWQACERFK QIPARNTQQL AQEARRIYDE FLSSHSVSPV NIDRQAWIGE
EMLAMPTPDM FRVQQLQIFN LMKFDSYARF VKSLLYQACV RAENEGQPLP PLRAHSRNSS
PPPDLGKKVK LKPGKSLPLG VEVAGSCAGR SPQRSFRRGE RREPSWTEVG DGNEGLSLWR
ESQGSLNSSA SLDLGFLSSS CSSSSMASSS RAESHRKSLG GAEPDPQARP SKYCCVYLPD
GTASLASVRA GVSIRDMLAG LCEKRGFSLP DIKVYLVGNE QKALVLDQDS VVLMDQEVKL
ENRISFELEI SPLSKTVRIT AKSNKCLREA LQPVLGKYDP ALAPHCAPSH ATLPDSVLLQ
QGEPGALDLK KLVSTVAAQK LILEAATEVK VTGASDAAVA TSPLRCKEGA PTDTEVEADM
LSEVPRSFTR SRPAAPRGVN RCTYDLEGLV ELVNRAQSCR ANDQRGLLSK EVLVLPDFLQ
LPGQDAGLSK SSERQHGPCD ASPTPKGAGA PCPLDPALAQ PPVHSELH
//
