ID M7B5F1_CHEMY Unreviewed; 889 AA.
AC M7B5F1;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=glycine dehydrogenase (aminomethyl-transferring) {ECO:0000256|ARBA:ARBA00012134};
DE EC=1.4.4.2 {ECO:0000256|ARBA:ARBA00012134};
GN ORFNames=UY3_09684 {ECO:0000313|EMBL:EMP33176.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP33176.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage
CC complex H protein] = CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-
CC L-lysyl-[glycine-cleavage complex H protein]; Xref=Rhea:RHEA:24304,
CC Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10495, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57305, ChEBI:CHEBI:83099,
CC ChEBI:CHEBI:83143; EC=1.4.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00043839};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
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DR EMBL; KB536908; EMP33176.1; -; Genomic_DNA.
DR AlphaFoldDB; M7B5F1; -.
DR STRING; 8469.M7B5F1; -.
DR eggNOG; KOG2040; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0004375; F:glycine dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC.
DR GO; GO:0006546; P:glycine catabolic process; IEA:InterPro.
DR CDD; cd00613; GDC-P; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 2.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 3.
DR InterPro; IPR049316; GDC-P_C.
DR InterPro; IPR049315; GDC-P_N.
DR InterPro; IPR020581; GDC_P.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11773:SF1; GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL; 1.
DR PANTHER; PTHR11773; GLYCINE DEHYDROGENASE, DECARBOXYLATING; 1.
DR Pfam; PF21478; GcvP2_C; 1.
DR Pfam; PF02347; GDC-P; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 2.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443}.
FT DOMAIN 5..409
FT /note="Glycine cleavage system P-protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02347"
FT DOMAIN 700..819
FT /note="Glycine dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21478"
SQ SEQUENCE 889 AA; 99062 MW; 2D162D4E89F7180E CRC64;
MDVLFQSIDE LIDRTVPASI RLRRPLEMDD HICENEILET LHNIASKNKI WRSYMGMGYY
NSSVPQAIVR NLLENAGWVT QYTPYQPEVS QGRLESLLNY QTMVCDITGM DVANASLLDE
GTAAAEAMQL CHRHNKRRKF YVDVRCHPQT IAVVQTRANY SSVVIELKLP HEMDFSGKEV
SGVLFQYPDT EGKVEDFTEL VDRAHQNGTL VCCATDLLAL CILRPPGEFG VDVALGNSQR
FGVPLCYGGP HAAFFAVKEN LVRMMPGRMV GVTRDANGKE VYRLALQTRE QHIRRDKATS
NICTAQALLA NMAAMYGVYH GSNGLKHIAR RVHNATLILA EGLKQAGHTL QHDLFFDTLK
IQCGCAVKEV FDRASQRQIN FRIYSDGTIG VSLDETVTER DLDDLLWIFG CESSSELVAE
SMGEETRGIL STAFKRTSKF LTHQVFNSYH SETNIVRYMK RLENKDISLV HSMIPLGSCT
MKLNSSSELA PITWKEFANI HPFVPLDQAQ GYQQLFRELE RDLCEITGYD KISFQPNSGA
QGEYAGLTAI KAYLNAKGER QRNVCLIPKS AHGTNPASAQ MAGMKIQPVE VDKNGNIDIA
HLKAMVGLCR PGDYGSDVSH LNLHKTFCIP HGGGGPGMGP IGVKNHLVPY LPSHPVLALQ
LDKDACPLGT ISAAPWGSSA ILPISWAYIK MMGGKGLKHA SEIAILNANY MAKRLEKHYK
VLFRGGYVAH EFILDARPFK KTANVEAVDV AKRLQDYGFH APTMSWPVAG TLMIEPTESE
DKAELDRFCD AMINIRQEIA EIEEGRMDST VNPLKMSPHT LTCITSPNWD RPYSREVAAF
PLPFVKPESK FWPTIARIDD IYGDQHLVCT CPPMEVYESP VSEQKRAAS
//
