ID M7B668_CHEMY Unreviewed; 332 AA.
AC M7B668;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=Mitochondrial genome maintenance exonuclease 1 {ECO:0000256|HAMAP-Rule:MF_03030};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_03030};
GN Name=MGME1 {ECO:0000256|HAMAP-Rule:MF_03030};
GN ORFNames=UY3_10201 {ECO:0000313|EMBL:EMP32634.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP32634.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- FUNCTION: Metal-dependent single-stranded DNA (ssDNA) exonuclease
CC involved in mitochondrial genome maintenance. Has preference for 5'-3'
CC exonuclease activity. Necessary for maintenance of proper 7S DNA
CC levels. Probably involved in mitochondrial DNA (mtDNA) repair.
CC {ECO:0000256|HAMAP-Rule:MF_03030}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03030}.
CC -!- SIMILARITY: Belongs to the MGME1 family. {ECO:0000256|HAMAP-
CC Rule:MF_03030}.
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DR EMBL; KB539463; EMP32634.1; -; Genomic_DNA.
DR AlphaFoldDB; M7B668; -.
DR STRING; 8469.M7B668; -.
DR eggNOG; ENOG502QVKE; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0008297; F:single-stranded DNA exodeoxyribonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0043504; P:mitochondrial DNA repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR HAMAP; MF_03030; MGME1; 1.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR PANTHER; PTHR31340; MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1; 1.
DR PANTHER; PTHR31340:SF3; MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000256|HAMAP-Rule:MF_03030};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_03030};
KW Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03030};
KW Nuclease {ECO:0000256|HAMAP-Rule:MF_03030};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443}.
FT DOMAIN 196..277
FT /note="PD-(D/E)XK endonuclease-like"
FT /evidence="ECO:0000259|Pfam:PF12705"
FT ACT_SITE 229
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03030"
FT ACT_SITE 242
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03030"
FT ACT_SITE 244
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03030"
SQ SEQUENCE 332 AA; 38001 MW; 06853F5D46659860 CRC64;
MLFTEHFCKD QVPSVCLCIS SYLCSKKKKE NGYEQVDQER YMNLVRSVTS SKASPQTPET
LFEEDNLIYG PVSKFKPPVK DVEAKIPKNW VPLINSNKRA LPSNSDGKHL LKISLQRHKM
PSVTSVLQQT MPLDQAFYLK RWKQRMILEL GKDGFAEYTK NIFFQGKLFH AALESVFLSE
EVPSKEQEKD TTVSGYLASV QHVLRDISGV KALESAVHHE ILHYSGLVDC VAEYRGQLCV
IDWKTSEKSK PYLRNTFDNP LQVAAYTGAI NHDANYDFQV NCGLIVVSYK DGSPAHPHFM
DSDLCSQYWN KWLLRLEEYT EKEKNNNSIE TS
//
