ID M7B9N3_CHEMY Unreviewed; 1496 AA.
AC M7B9N3;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Protein CASC3 {ECO:0000256|ARBA:ARBA00019964};
GN ORFNames=UY3_09138 {ECO:0000313|EMBL:EMP33844.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP33844.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CASC3 family.
CC {ECO:0000256|ARBA:ARBA00009548}.
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DR EMBL; KB535131; EMP33844.1; -; Genomic_DNA.
DR STRING; 8469.M7B9N3; -.
DR eggNOG; KOG4264; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0035145; C:exon-exon junction complex; IEA:InterPro.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 6.10.250.2000; -; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR018545; Btz_dom.
DR InterPro; IPR029332; PEHE_dom.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR13434; PROTEIN CASC3; 1.
DR PANTHER; PTHR13434:SF0; PROTEIN CASC3; 1.
DR Pfam; PF09405; Btz; 1.
DR Pfam; PF15275; PEHE; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM01044; Btz; 1.
DR SMART; SM01300; PEHE; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1248..1494
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 74..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 977..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 15..42
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 377..408
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..532
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..680
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..721
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..753
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..1005
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1496 AA; 170056 MW; 507BBC5FAE9E3E96 CRC64;
MKACRLKRKC WPWFLFQLLA RIERMERRMQ LVKKDNEREK HRIFQGYETE EKAESEASEK
LQIECQQDLL DTSQPLPPKH FSYGRNGKGH KRKSAFGSAE RKTPVKKLVA EFSKVKNKTL
KHSPVKEEPS SSLSETVCRR ELRSQETPEK ARSLVDAPLK PSTPLKSPSA HPRDKSFPSE
TEDLPYLSTT EMYLCRWHQP PPSPLPLREP SPKKEETVAI PSWRDHAVEP LRDSNPSDLL
ENLDDSVFAK RHAKLELDEK RRKRWDIQRI REQRILQRLQ LRMYKKKGIQ ESEPEVTSFF
PEPDDVESLL ITPYLPVVAF GRPLPKLTPQ NFELPWLDER SRCRLEMQKK QTPHRTTTSF
RISFHCSNKD CTDTVAQESE DGIEGDAVLS DYESAEDSEA EEGEYSEEES SKVELKQESN
NASESTGKAE KGEEKPDPKG AVTGERQSGD GQESTEPAEN KVGKKVPKHL DDDEDRKNPA
YIPRKGLFFE HDLRGQAQEE EVRPKGRQRK LWKDEGRWEH DKFREDEQAP KSRQELIALY
GYDIRSAHNP DDIKPRRMRK PRFGSPPQRE PNWANERQNK PPRHQDSDSA PLPTRTFISR
HSAGMGRMPP ARNVPRVGGY KENRPSYRAV EANSQHLSRT GEQAKHESSY RARRVEQAPE
RDPSPEAESA HVHSSPAKKE EIILESQTPS TDSVQPPPDR PIEKKSYSRA RRTRNKAGDA
GKLADEVPPP EGLTPVPPKP VQVVTPPPPA KAGSWETPVE SSMDGLEQDM TQLNLTEQSW
TQGQPPFIPP RELRGIPNHM HMGAGPPPPF NRMEEMGVQG GRAKRYSSQR QRPPVPEPAP
PMHISIMEGH YYDPLQFQGP IYTHSENPAP LPPQGMIVQP EMHLPHPGLH PHQTPAPLAN
PGLYPPPVSM PPGQPPPQQL LAPTYFSPPG VMNFGNPSYP YPPGALPPPP PPHLYPSTQA
QAQVYGGVTY YNTVQQQVQP KPSPPRRTSQ PVTIKPPPPE TNTPPSLQSS PWLLFAPNWV
LQTERYRHLL AKPNHCCTLT DVLLDDVILT HSLFLPTERL LRELHQRYPS GEGPELPGLF
SLNPVPTFLL ASGGPSPGWA ASDARPRKRA VLTVLLHFLE TYKGILQEEE SAGKVIKDLY
LLIMKDVSLY PELEDEILRL HQLVERAELK VPEEIPPPSK QVKPLFRHFR RIDSCLQTRV
AFRGSDEIFC RVYMPDHSYV TIRSRLSASV QDILAAVTEK LQYSEEQGAR EEALALVVVA
SSGEKAVLQP SEECVFTTLG INSHLFACTK DAIESLVPLP EEIQVSPGDT EIHRAEAEEI
ANHLTAFHWE LFRCIHEVRC KQNQDMLSFY AVVMGLDNAA VSRLRLTWEK LPGKFKNLFR
KFETLTDPCR NHKTYREVLS KMNPPLIPFV PLILKDLTFV HEGSKTLLDG LVNVEKLHSI
AEKVRTIRKY RSRPLCLDLE ASPSQLQTKA YVRQFQVIDN QNLLFELSYK LEASSQ
//
