ID M7BAL9_CHEMY Unreviewed; 189 AA.
AC M7BAL9;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Apolipoprotein C-II {ECO:0000256|ARBA:ARBA00013947, ECO:0000256|RuleBase:RU368054};
DE Short=Apo-CII {ECO:0000256|RuleBase:RU368054};
DE Short=ApoC-II {ECO:0000256|RuleBase:RU368054};
DE AltName: Full=Apolipoprotein C2 {ECO:0000256|ARBA:ARBA00031176, ECO:0000256|RuleBase:RU368054};
GN ORFNames=UY3_17674 {ECO:0000313|EMBL:EMP25262.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP25262.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- FUNCTION: Component of chylomicrons, very low-density lipoproteins
CC (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins
CC (HDL) in plasma. Plays an important role in lipoprotein metabolism as
CC an activator of lipoprotein lipase. {ECO:0000256|RuleBase:RU368054}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU368054}.
CC -!- SIMILARITY: Belongs to the apolipoprotein C1 family.
CC {ECO:0000256|ARBA:ARBA00009204}.
CC -!- SIMILARITY: Belongs to the apolipoprotein C2 family.
CC {ECO:0000256|ARBA:ARBA00007221, ECO:0000256|RuleBase:RU368054}.
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DR EMBL; KB592659; EMP25262.1; -; Genomic_DNA.
DR AlphaFoldDB; M7BAL9; -.
DR STRING; 8469.M7BAL9; -.
DR eggNOG; ENOG502TDK3; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0042627; C:chylomicron; IEA:UniProtKB-UniRule.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-UniRule.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-UniRule.
DR GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-UniRule.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR Gene3D; 4.10.260.30; Apolipoprotein C-I; 1.
DR Gene3D; 1.10.1440.10; Apolipoprotein C-II; 1.
DR InterPro; IPR008019; Apo-CII.
DR InterPro; IPR043081; ApoC-1_sf.
DR InterPro; IPR006781; ApoC-I.
DR InterPro; IPR023121; ApoC-II_dom_sf.
DR PANTHER; PTHR16566; APOLIPOPROTEIN C-II; 1.
DR PANTHER; PTHR16566:SF0; APOLIPOPROTEIN C-II; 1.
DR Pfam; PF05355; Apo-CII; 1.
DR Pfam; PF04691; ApoC-I; 1.
PE 3: Inferred from homology;
KW Chylomicron {ECO:0000256|ARBA:ARBA00022513, ECO:0000256|RuleBase:RU368054};
KW HDL {ECO:0000256|ARBA:ARBA00022850, ECO:0000256|RuleBase:RU368054};
KW LDL {ECO:0000256|ARBA:ARBA00022710, ECO:0000256|RuleBase:RU368054};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963,
KW ECO:0000256|RuleBase:RU368054};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW ECO:0000256|RuleBase:RU368054};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU368054};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU368054};
KW Signal {ECO:0000256|RuleBase:RU368054, ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU368054};
KW VLDL {ECO:0000256|ARBA:ARBA00023313, ECO:0000256|RuleBase:RU368054}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..189
FT /note="Apolipoprotein C-II"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004079915"
SQ SEQUENCE 189 AA; 21479 MW; 4E7AC27BF69BF2D2 CRC64;
MRPAVSISLI LVALTVLADS AQAQPTELTL SEKFENFQNR LQAFADSIAN ITKAAFQELH
HSELSEKTRC TCFIWFVGFR ALLESQEGAT LSTTANMGQM DLKIAVAFIL LLFLCTEAAS
YRLQKREAQD SFSQIQEVAK NYWERLNSVV QGWLDSVKSW DIYEKTTSAA GTYTEILKDQ
VYHWWHGEQ
//
