ID M7BB37_CHEMY Unreviewed; 1811 AA.
AC M7BB37;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Putative E3 ubiquitin-protein ligase HERC3 {ECO:0000313|EMBL:EMP29348.1};
GN ORFNames=UY3_13556 {ECO:0000313|EMBL:EMP29348.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP29348.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00104}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB557013; EMP29348.1; -; Genomic_DNA.
DR STRING; 8469.M7BB37; -.
DR eggNOG; KOG0941; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 2.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 4.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR PANTHER; PTHR45622:SF58; HECT AND RLD DOMAIN CONTAINING E3 UBIQUITIN LIGASE 4, ISOFORM C; 1.
DR PANTHER; PTHR45622; UBIQUITIN-PROTEIN LIGASE E3A-RELATED; 1.
DR Pfam; PF00632; HECT; 2.
DR Pfam; PF00415; RCC1; 11.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 2.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 2.
DR PROSITE; PS50237; HECT; 2.
DR PROSITE; PS00626; RCC1_2; 5.
DR PROSITE; PS50012; RCC1_3; 11.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT REPEAT 71..123
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 124..175
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 176..227
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 229..294
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 514..652
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REPEAT 719..772
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 773..822
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 823..875
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 876..928
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 929..1020
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 1021..1072
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 1074..1140
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 1484..1811
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 1779
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1811 AA; 201997 MW; 48657F0C1F87F8D7 CRC64;
MSLLSPPPQP AGAASSLLLL VPKSNCHPNF FKKHPQEISQ INCKESSLAI VERNGSVLIF
DKEGEHRKPG GELFTWGQNS HGQLGVGNQI DFIHKPQLVQ ELRGIPLAQI AAGGTHSLAL
SLSGAVYSWG KNDFGQLGLG DTENKYYPSY IRALEHKKTV YISCGGEHTA VLSQDGLVCT
FGAGDYGQLG HNSTQNELTP RIVAELFGAR VSQIACGRWH TLVYVPSLGK VYSFGCGAEG
QLGNGDTSNQ LIPLPVELPS DWVNGGKLNP GNSTSKKVIK IIAGGNQSIV LCLKKKNPYV
TLNGTAIAEH KEVDKWISNS DPKQWENIKK NIRLIFSSVA CVNGSFLDKS GDKHFRTSKE
ISGVDMSAVL LFYEKMNKKP KGLQEVISAV EKLLSSLSSS PSSPEALRIY LIIPVLLRGQ
DNVSNRLLDR LAEAILSLQQ KDLKVLGKKD LLKLTAYPCI FDMQDKIVVY EIDRQILFRI
YNANSFLVPR GPWCIEIRRA HLVDDVWQYL RSAQPKTFEK FLKVQFVGEQ GIDDGGLSQE
LFTIITRELC CPEAQIFRSL EDSKLIWFPS QVPGSEDTFF LIGTLFGMAL YNMKIAPFHF
PLALYKKLLD IPPTLEDLKE LSPTEGRNLQ EMLNEDYDDI LENMMMDFTI DTYRKELYRI
DECCYLIVFL EPKLHLEQQP HLGMCWTMSS ACSYVVDSTP DLLKTGQGRK KLHDLLKGEK
MLCWGCWSFG QPGIGSNLQA IIPEPQVYGF IHDRNIKEVA CGGNHSVFLL ENGEVYTCGL
NTKGQLGHQS EGSKPEQIGA LADQHIVHVA CGESHSVALS DQGQLFAWGA GSDGQLGITT
TEDSVAVPRL IKKLNQQTIL QVSCGNWHCL ALAADGQFFT WGQNNYGQLG LGKECPSQTS
PQRVTSLDGI PLAQVAAGGA HSFALSLSGA VFGWGRNNSG QLGLSDEQGD SYQGFGNKLP
SSVLEGGMSV KVDLIRIPNP LSHANQSTDR ESPCHVKLLR TQKVVYISCG EEHTAVLTKS
GGVFTFGAGS CGQLGHDSMN DEVNPRRVLE LMGTEVSQIA CGRQHTLALV PSSGLIYAFG
CGTKGQLGTG HICNVKCPSP VKGHWVAHNG QLSGRADAFK YHIVKHIFCG GDRTFVLCSK
SENSLPADDF RTINQLCYTC LINDETIAVW KQKLLERNSS NSVNSEVVQI LSSSACWNGS
FLEKKIDEHF KTSPKIPGID LNSTRVLFEK LMNSQHSILL DQILKSFESF LIPQLSSSPP
DVEAMRIYLI LPEFPLFQDS KHYITLTLPL AMAILRLDTN PSKVLDNWWS QVCPRYFLRL
VNLYKGAVVY LLNGRKTLLI PVLFSSYITA ALRLLEKLHK VNLKVKHVEY DTFYIPEISN
LVDIQEDYLM WFLHQAGKKV RPSIMQDAVT LCSYPFIFDA QAKTKMLQTD AELQMQVAIN
GANLQNVFML LTLEPLLARS PFLVLHVRRS NLVGDALREL SIHSDIDLKK PLKVIFDGEE
AVDAGGVTKE FFLLLLKELL NPIYGMFIYY PESNLLWFSD TCFVEHNWFH LIGIVCGLAI
YNFTVVDLHF PLALYKKLLN VKPCLEDLKE LSPTEGRSLQ QLLDYPGDDV EETFCLNFTI
CRESYGVTEQ KKLIPEGDKI TVQKDNRQEF VEAYLNYIFN LSVHEWYIAF STGFLKVCGG
KVLELFQPSE LRAMIVGNSN YNWEEMEECA IYKGDYSATH PTVRMFWETF HEFPLEKKKK
FLLFLTGSDR IPIYGMSSLR IIIQSTSSGD QYLPVAHTCY NLLDLPKYSS KETLSVRLTQ
AIDHYEGFSL A
//
