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Database: UniProt
Entry: M7BBD2_CHEMY
LinkDB: M7BBD2_CHEMY
Original site: M7BBD2_CHEMY 
ID   M7BBD2_CHEMY            Unreviewed;       343 AA.
AC   M7BBD2;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   11-DEC-2019, entry version 30.
DE   RecName: Full=GLUCAGON domain-containing protein {ECO:0000259|PROSITE:PS00260};
GN   ORFNames=UY3_07583 {ECO:0000313|EMBL:EMP35256.1};
OS   Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia;
OC   Chelonioidea; Cheloniidae; Chelonia.
OX   NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP35256.1, ECO:0000313|Proteomes:UP000031443};
RN   [1] {ECO:0000313|Proteomes:UP000031443}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA   White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA   Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA   Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA   Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT   into the development and evolution of the turtle-specific body plan.";
RL   Nat. Genet. 45:701-706(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00134107}.
CC   -!- SIMILARITY: Belongs to the glucagon family.
CC       {ECO:0000256|SAAS:SAAS00593530}.
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DR   EMBL; KB529023; EMP35256.1; -; Genomic_DNA.
DR   STRING; 8469.XP_007060410.1; -.
DR   Proteomes; UP000031443; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0048255; P:mRNA stabilization; ISS:AgBase.
DR   GO; GO:0070459; P:prolactin secretion; ISS:AgBase.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   InterPro; IPR029180; Myc_target_1.
DR   InterPro; IPR015523; VIP.
DR   PANTHER; PTHR11213:SF5; PTHR11213:SF5; 1.
DR   Pfam; PF00123; Hormone_2; 2.
DR   Pfam; PF15179; Myc_target_1; 1.
DR   SMART; SM00070; GLUCA; 2.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW   Secreted {ECO:0000256|SAAS:SAAS00134090};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        168..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          290..312
FT                   /note="GLUCAGON"
FT                   /evidence="ECO:0000259|PROSITE:PS00260"
SQ   SEQUENCE   343 AA;  38476 MW;  0E667546FE819983 CRC64;
     MFIFCVLGQM IIAFSVSMVI GLVIGGIIWA LFTCLSRRRA SAHISQWSSS ISSRRSRPAS
     QGHAANRTGF YRNNSCERRS NLSLASLTFQ RQASLEQANS FPRKSSFRAS TFHPFLQCPP
     LPVETNSQLI TLSPTSTTTT LVGTTTNSLT RPEFHWSSMM EHRSSSQLLL SFTLFSVLCS
     PALALPPLGT YSAMRLGNRM PFDGASEPDQ AQGSLKPETD ILPNALPEND KFYFDMSRAI
     DRNARHADGL FTSGYSKLLG QLSARRYLES LIGKRVSNNL MDEQMPVKRH SDAVFTDNYS
     RFRKQMAVKK YLNSVLTGKR RPRQLRAPSL MLLFSQLRRN IGE
//
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