ID M7BBP2_CHEMY Unreviewed; 1454 AA.
AC M7BBP2;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Rab GTPase-activating protein 1 {ECO:0000313|EMBL:EMP34594.1};
GN ORFNames=UY3_08170 {ECO:0000313|EMBL:EMP34594.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP34594.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; KB532021; EMP34594.1; -; Genomic_DNA.
DR STRING; 8469.M7BBP2; -.
DR eggNOG; KOG1102; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd00637; 7tm_classA_rhodopsin-like; 1.
DR CDD; cd01211; PTB_Rab6GAP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 1.10.10.750; Ypt/Rab-GAP domain of gyp1p, domain 1; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR044822; Myb_DNA-bind_4.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR PANTHER; PTHR47219:SF6; RAB GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF13837; Myb_DNA-bind_4; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 786..807
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 828..851
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 871..896
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 935..956
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 152..267
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 566..1193
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT DOMAIN 727..986
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 1..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1185..1350
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1378..1426
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 9..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..94
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1454 AA; 164783 MW; FE604BBBEA5150DE CRC64;
MDDKVSVGKI SVSSDSVSTL NSEDFVLVSR QGDETPSTNN GSDDEKTGLK IVGNGSEQQL
QRELEDVLMD PPMEDLSSDR EHGEESRTDG EGEDPILLEA SASSTINPVS MTGLQKPEMS
LPVKPTQGDC EDSSPFTPVA DEDSVVFSKL TYLGCASVNA PRSEVEALRM MSILRSQCEI
SLDVTLSVPN VSEGTVRLLD PQTHTEIANY PIYKILFCVR GHDGTPESDC FAFTESHYNA
ELFRIHVFRC EIQEAVSRIL YSFATAFRRS AKQTPLSATE APQTPDSDIF TFSVSLEIKE
DDGKGYFSAV PKDKDRQCFK LRQGIDKKIV IYVQQTTNKE LAIERCFGLL LSPGKDVRSG
DMHLLDLESM GKSSDGKSYV ITGSWNPKSP HFQIVNEETP KDKVLFMTTA VDLVITEVQE
PVRFLLETKV RVCSPNERLF WPFSKRSSTE NFFLKLKQIK QKDRKNNTDT LYEVVCLESE
SERERRKTTA SPSIRLPQSG SQSSMIPSPP EDDEEEDNDE PLLSGSGDVS KECAEKILET
WGDLLSKWHL NLSVRPKPLS ALVRSGVPEA LRGEVWQLLA GCHNNDHLVE KYRILITKDM
KDPGHNRDPK QCCMKLKELR QAYQKTREAN GRSGSEPQTC RFYDQLHAIL RGSATTTPAM
LFDSFSGDGG NTEAGYGDEK DSSQQASGET GFPDSQELFL TLDLEPVPPE PTQGCLLDPA
GGEGTSGNII VIFVFHCAPL LNHHTTSYFI QTMAYADLLV GVSCLVPSLS LLHYPIVLRE
SLVCQVFGYV VSVLKSVSMA SLACISIDRY IAITKPLTYN TLVTPWRLRV CILIIWLYSC
VVFLPAFFHW GKPGYHGDVF QWCANSWYTD RYFTLFIVMM LYAPAAFIVC FTYFNIFRIC
QQHTKEINER RVRFSSQDGE AGEAQHCPDK RYAMVLFRIT SVFYILWLPY IIYFLLESSA
VYRNHTASFL TTWLAISNSF CNCVIYSLSN SVFQKGLKRL SGVVCTSCAR QRSGYMSDLT
VAQLHQYSCS AESPQDSAIT RDINRTFPAH DYFKDTGGDG QDSLYKICKA YSVYDEEIGY
CQGQSFLAAV LLLHMPEEQA FSVLVKIMFD YGLRELFKQN FEDLHCKFYQ LERLMQGISV
IFNVALGLLK TTKDDLLLTD FEGALKFFRV QLPKRYRSEE NAKKLMELAC NMKIGQKKLK
KYEKEYHTMR EQQAQQEDPI ERFERENRRL QEANMRLEQE NDDLAHELVT SKIALRKDLD
NAEEKADALN KELLMTKQKL IDAEEEKRRL EEESAQLKEM CRRELDKAES EIKKNSSIIG
DYKQICSQLS ERLEKQQTAN KAEIEKIRQK VDDCEHCREF FNKEGRVKVA SSAKEASDED
TDEEKESLKN QLREMELELA QTKLQLVEAE CKIQDLEHHL GLALNEVQAA KKTWFNRTIS
SIKTVTGVQG KETC
//
