ID M7BD50_CHEMY Unreviewed; 445 AA.
AC M7BD50;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Rap guanine nucleotide exchange factor 4 {ECO:0000313|EMBL:EMP35104.1};
GN ORFNames=UY3_07759 {ECO:0000313|EMBL:EMP35104.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP35104.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
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DR EMBL; KB529800; EMP35104.1; -; Genomic_DNA.
DR AlphaFoldDB; M7BD50; -.
DR STRING; 8469.M7BD50; -.
DR eggNOG; KOG2378; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF175; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443}.
FT DOMAIN 1..68
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 206..443
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 445 AA; 51044 MW; 6809EF52A28A4B38 CRC64;
MDYALNNKRR VLRLVLQWAA SYGDLLQEDE AAVAFLEEFY VSVSDDARII TALKEQLSEL
EKTVKQISEE TKAPQKKHKI LLQQFNTTDD RAQKRQPIRG SDEILFKVYC IDHTYTTIRV
PVMASVKEVI SAVADKLGSG EGLIIVKMSS GGEKVVLKPN DGSAFTTLSV NGRLFACPRD
QFDSLTPLPE QEGPSAGTVG TFELMSSKDL AYQMTIYDWE LFNCVHELEL IYHTFGTHNF
KKTTANLDLF LRRFNEIQFW VVTEICLCSQ LSKRVQLLKK FIKIAAHCKE YKNLNSFFAI
IMGLSNVAVS RLSLTWEKLP SKFKKIYAEF ESLMDPSRNH RAYRLTVAKL DPPIIPFMPL
LIKDMTFTHE GNKTFIDNLV NFEKMRMIAN TARTVKFCRS QSFNPDAALT NKNHQDVRTY
VRQLNVIDNQ RTLSQMSHRL EPRRA
//
