ID M7BQ12_CHEMY Unreviewed; 500 AA.
AC M7BQ12;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Fascin {ECO:0000256|PIRNR:PIRNR005682};
GN ORFNames=UY3_12625 {ECO:0000313|EMBL:EMP30252.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP30252.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR005682}.
CC -!- SIMILARITY: Belongs to the fascin family.
CC {ECO:0000256|ARBA:ARBA00007415, ECO:0000256|PIRNR:PIRNR005682}.
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DR EMBL; KB550906; EMP30252.1; -; Genomic_DNA.
DR RefSeq; XP_007065838.1; XM_007065776.1.
DR AlphaFoldDB; M7BQ12; -.
DR eggNOG; ENOG502RGDE; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR Gene3D; 2.80.10.50; -; 4.
DR InterPro; IPR008999; Actin-crosslinking.
DR InterPro; IPR010431; Fascin.
DR InterPro; IPR022768; Fascin-domain.
DR InterPro; IPR024703; Fascin_metazoans.
DR PANTHER; PTHR10551; FASCIN; 1.
DR PANTHER; PTHR10551:SF23; FASCIN; 1.
DR Pfam; PF06268; Fascin; 4.
DR PIRSF; PIRSF005682; Fascin; 1.
DR SUPFAM; SSF50405; Actin-crosslinking proteins; 4.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR005682};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005682};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR005682};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443}.
FT DOMAIN 18..141
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 157..262
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 278..383
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 421..499
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
SQ SEQUENCE 500 AA; 54798 MW; 048EB7ADC60CFB2F CRC64;
MADSTLPPSL PCGLINAANR YLSAEPFRFQ VVATGSVLRL RQVWMLRFMP SQGAGAAGQA
EESGQRLHLL SSLQRFLAAD PNGKVTCDQE SPGPGALFLL RQYPDGKVSL QCELSQRYLG
GAEDNVTCFA QTVSEGEKWS LHLAQHPNGH MLNLGKQRYM RCDQQTGHMR CDRDLPWGPE
AVITLHFDLK ERKYGLWSGA GSLLAADGSL QAELSPQTLY SLELRGGLLA LRDADGRYLT
GRENTVKTFK TDKPGRDEFF ALEPSAAQVT LRTFTGGHFV CCRPGADIYA NAMSVGNTEI
FQLLLNDVTK QACFRSSSGT YLAVGPNDSV VSTSAHDKGV WFSLQYREQR VTLRMADGRQ
VATRPNGQLL LVPEAAGKKE EFLLLLVNRP LLILQSEAGF VGLFPGTQRL DGNRPAYDAS
TLTLSEDGFC HFRVANKYWS LDKDGLVMAS EDHPSNFSLQ FVSSSCLVLK APNKKYLVVE
AGGRLWAGAS DAASATPFRY
//
