ID M7BQX3_CHEMY Unreviewed; 959 AA.
AC M7BQX3;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Ankyrin repeat and LEM domain-containing protein 2 {ECO:0000313|EMBL:EMP40291.1};
GN ORFNames=UY3_02454 {ECO:0000313|EMBL:EMP40291.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP40291.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- SIMILARITY: Belongs to the ANKLE2 family.
CC {ECO:0000256|ARBA:ARBA00007597}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB514175; EMP40291.1; -; Genomic_DNA.
DR AlphaFoldDB; M7BQX3; -.
DR STRING; 8469.M7BQX3; -.
DR eggNOG; ENOG502QQ4Z; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd12944; LEM_ANKL2; 1.
DR Gene3D; 1.10.720.40; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.970.10; Ribonuclease H1, N-terminal domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011015; LEM/LEM-like_dom_sf.
DR InterPro; IPR035006; LEM_ANKL2.
DR InterPro; IPR003887; LEM_dom.
DR InterPro; IPR011320; RNase_H1_N.
DR InterPro; IPR037056; RNase_H1_N_sf.
DR PANTHER; PTHR12349; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR12349:SF4; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF01693; Cauli_VI; 1.
DR Pfam; PF03020; LEM; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00540; LEM; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF63451; LEM domain; 1.
DR PROSITE; PS50954; LEM; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443}.
FT DOMAIN 5..49
FT /note="LEM"
FT /evidence="ECO:0000259|PROSITE:PS50954"
FT REGION 428..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 877..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 959 AA; 106900 MW; A4CA2D49CC05CC8B CRC64;
MDTILSRLKQ LTPDDLREEI VKAGLKCGPI TSTTRFIFEK KLAQFLLEQQ GGLEINASTL
SEKSSENIAF HSSQSEIQRA WKSTAVNHKS HVNVSEEGDF GYNMGLNPPE EEVVMHKTCS
ASVCGGVDVD SQINAQTPSR DPPLYYGVCP VYDDILARNE KVHVYDDKKE ALQAVKMIKG
SRFKAFSNRE DAEKFAKGIC DYFPSPSKSS LSSSPVKIGP LFNRDGLCSP ETETVNKERA
NSYKSPRTQD LTAKLRKAVE KGDEATFSEL IWSNPRYLIG SGDNPTIVQE GCRYNVMHVA
AKENQAGISQ LLLDTLENPE FMRLMYPDDD EVMLQERIRY IVDLYLNTPD KMVFDTPLHF
ACKFGNLDVV NVLTSHPDIV KNPKNKYGQT PAEVICERNK NKSVELKEKI REYLKGRYYV
PLLRAEDNSS SPVIGAPWSP DQSDDNPLTA LPKHSGSPKD PVLSVRAFAG PMTPSKAEEF
RKLWKTPPRE RAGFFHNVRK SDPERGVERV GRELAHELGF PWVEYWEFLG CFVDLSSQEG
LRKLEEYLSQ REMSEKAQQE TGENETCNRY KTPHSSGKSK KCCNSISVGA FLDEDDDDMS
LEEIKNRQNA ARNNSPPVVS KESSIDAIGD SECDILSMEH KVNLIETSDL SMQYEKGVSS
SKNGFCSPVT NEKITSDRKH SRGGEECLIS PVSNLMAEFE RLSFQDEAVA GECLVVKSNK
IIAKTENERI LAEGMNQVRI SKDQLGKTCS ALSMASCSEP ATTEKPGDTK LRTENKIPSE
AERLSLDPGI WDKETQQLGS LAVQSECAAY LCQEPSPQRF LLKTPPTNEN TNKLFLFGEQ
PSKLDSDVLA AVEGVEIDPQ KYPITYKWKN AVKSYSSSDR QSWPSPALKG RFKSQSLAAG
PPNGSTYSRR NSPVMGSPGK YGNVASFFPD LGSPGRYSPV YANNILLLKL HHLSEPSAH
//
