ID M7BUI7_CHEMY Unreviewed; 715 AA.
AC M7BUI7;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Mitofusin-2 {ECO:0000313|EMBL:EMP41511.1};
DE Flags: Fragment;
GN ORFNames=UY3_01219 {ECO:0000313|EMBL:EMP41511.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP41511.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004374}.
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DR EMBL; KB489737; EMP41511.1; -; Genomic_DNA.
DR AlphaFoldDB; M7BUI7; -.
DR STRING; 8469.M7BUI7; -.
DR eggNOG; KOG0448; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0008053; P:mitochondrial fusion; IEA:InterPro.
DR CDD; cd09912; DLP_2; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR006884; Fzo/mitofusin_HR2.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR027094; Mitofusin_fam.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10465:SF1; MITOFUSIN-2; 1.
DR PANTHER; PTHR10465; TRANSMEMBRANE GTPASE FZO1; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF04799; Fzo_mitofusin; 1.
DR SUPFAM; SSF111479; Fzo-like conserved region; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 609..627
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..322
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT COILED 680..707
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EMP41511.1"
SQ SEQUENCE 715 AA; 81287 MW; A2C6276A38ED404F CRC64;
MAEVNASPLK HFVTAKKKIN GIFEQLAAYI QESSTFLEET HRNVELDPVT TEEQVLEVKG
YLSKVSGISE VLARRHMKVA FFGRTSNGKS TVINAMLWDK VLPSGIGHTT NCFLRVEGTD
GHDAFLLTEG SEEKRSVKTV NQLAHALHQN EFLNAGSLVS VMWPNSKCPL LKDDLVLMDS
PGIDVTTELD SWIDKFCLDA DVFVLVANSE STLMQTEKQF FHKVNERLSC PNIFILNNRW
DASASEPEYM EEVRRQHMER CTSFLVDELG VVDRAQAGDR IFFVSAKEVL NARIQKAQGM
PEGGGALAEG FQVRMFEFQN FERRFEECIS QSAVKTKFEQ HTVRAKQIAE DVRLIMDSLH
IAAQEQRVYC LEMREERQER LGFIDKQLEL LTQDYKVKIK QITEEVERQV SNAMAEEIRR
LSVLVDDYQM DFHPSPVVLK VYKNELHRHI EEGLGRNMSD RCSNAIAASL QTMQQEMIDG
LKPLLPVSLR GQIDMLIPRQ CFALSYDLNC DKLCADFQED VEFHFSLGWT MLVNRFLGPK
NSRRALMGYN DQIQRPLPLT PANPSLPPLP QGSMTQEELM VSMVTGLASL TSRTSMGILV
IGGVVWKAVG WRLIALSFGL YGLLYVYERL TWTMKAKERA FKRQFVEYAS EKLQLIVSYT
GSNCSHQVQQ ELAGTFAHLC QQVDVTRENL EQEIAAMNKK IEILDSLQSK AKLLR
//
