ID M7BVC0_CHEMY Unreviewed; 727 AA.
AC M7BVC0;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=Ras GTPase-activating protein 1 {ECO:0000313|EMBL:EMP41149.1};
GN ORFNames=UY3_01567 {ECO:0000313|EMBL:EMP41149.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP41149.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
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DR EMBL; KB497515; EMP41149.1; -; Genomic_DNA.
DR AlphaFoldDB; M7BVC0; -.
DR STRING; 8469.M7BVC0; -.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd08400; C2_Ras_p21A1; 1.
DR CDD; cd13260; PH_RASA1; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10194:SF146; RAS GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 2.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}; SH3 domain {ECO:0000256|ARBA:ARBA00022443}.
FT DOMAIN 20..110
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 139..242
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 247..355
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 413..578
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
SQ SEQUENCE 727 AA; 82292 MW; 5E12497DF32B342E CRC64;
MLLLLGAVWG GASPEPTFWW YHGKLDRTIA EERLRQAGKP GSYLIRESDR RPGSFVLSFL
SKTNVVNHFS FLKGDMFIVH NELEDGWMWV TNLRTDEQGL IVEDLVEEVH QEQVLNDTVD
GKEIYNTIRR KTKDAFYKNI VKKGYLLKKS KGKRWKNLYF ILEGNDAQLI YFESEKRATK
PKGLIDLSVC SVYGVHDSLF GRPNCFQIVV QHFSEEHYIF YFAGETPEQA QDWMKALQTF
CNLRKTSPGT SNKRLRQVSS LILHVEEAHT LPVKHFTNPY CNIYLNSVQV AKTHVREGQN
PVWSEEFVFD DLSPDINRFE ITLSNKTKKS KDPDILFMRC QLNRLQKGHA TDEWFQLSSH
IPLKGIEPGS LRVRARYSME KIMPEDEYSE FKELILQKEL HVVYALSHVC GQDRTLLAGI
LLKIFLHEKL ESLLLRTLND REISMEDEAT TLFRATTLAS TLMEQYMKAT ATSFVHHALK
DSILKIMESK QSCELNPSKL EKNEDVNTNL THLLSILSEL VEKIFMAAEI LPPGFVFLRL
ICPAILNPRM FNIISDSPSS TAARTLTLVA KSVQNLANLV EFGAKEPYME GVNPFIKSNK
HRMIMFLDEL GNVPELPDTT EHSRTDLSRD LAALHEICVA HSDELRTLSN ERGVMQGVAG
GGSQDYFRGA ALTSALRSEL GGRREAAADQ GSSSEGSRGE VRVAIPHQAI LTSALLLAAA
LSSEPGP
//