ID M7BX00_CHEMY Unreviewed; 917 AA.
AC M7BX00;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=5'-3' exoribonuclease 2 {ECO:0000313|EMBL:EMP32652.1};
DE Flags: Fragment;
GN ORFNames=UY3_10219 {ECO:0000313|EMBL:EMP32652.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP32652.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- SIMILARITY: Belongs to the 5'-3' exonuclease family. XRN2/RAT1
CC subfamily. {ECO:0000256|ARBA:ARBA00006994}.
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DR EMBL; KB539463; EMP32652.1; -; Genomic_DNA.
DR AlphaFoldDB; M7BX00; -.
DR STRING; 8469.M7BX00; -.
DR eggNOG; KOG2044; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0004534; F:5'-3' RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 3.40.50.12390; -; 2.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR InterPro; IPR017151; Xrn2/3/4.
DR PANTHER; PTHR12341:SF77; 5'-3' EXORIBONUCLEASE 2; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF17846; XRN_M; 1.
DR Pfam; PF03159; XRN_N; 1.
DR PIRSF; PIRSF037239; Exonuclease_Xrn2; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 15..228
FT /note="Xrn1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03159"
FT DOMAIN 300..743
FT /note="Xrn1 helical"
FT /evidence="ECO:0000259|Pfam:PF17846"
FT REGION 85..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..484
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EMP32652.1"
SQ SEQUENCE 917 AA; 105154 MW; A09DFD574EE64749 CRC64;
KECNGIKIPV DTSKPNPNEV EFDNLYLDMN GIIHPCTHPE DKPAPKNEDE MMVAIFEYID
RLFNIVRPRR LLYMAIDGVA PRAKMNQQRS RRFRASKEGV EGAEEKQRIR QEILAKGGFL
PPEEVKERFD SNCITPGTEF MDNLAKCLRY YIADRLNNDP GWKNLTVILS DASAPGEGEH
KIMDYIRRQR AQPNHDPNTH HCLCGADADL IMLGLATHEP NFTIIREEFK PNKPKPCGLC
SQFGHEVKDC QGLPREKQGE HDQFADCPPG SEQEFIFIRL SVLREYLEKE LTMASLPFTF
DIERSVDDWV FMCFFVGNDF LPHLPSLEIR EGAIDRLVGI YKNVVHKTGG YLTESGYVNL
QRVQMIMLAV GEVEDSIFKK RKDDEENFRR RQKEKRKRMK RDQPSFIPGG QFSPQALGRG
NRSSPQAISN PRQTAYEMRM QDKQNLTPST SPNTSFTSDG TPSPAGGIKR KAEDSDSEPE
PEDNIRLWES GWKQRYYKNK FDVDVSDEKF RRKVVQSYVE GLCWVLRYYY QGCASWKWYY
PFHYAPFASD FEGIADLPSD FEKGTKPFRP LEQLMGVFPA ASGNFLPPTW RKLMTDPESS
IIDFYPEDFA IDLNGKKFAW QGVALLPFVD ERRLRAALEE VYPDLTPDEN RRNSLGGDVM
FVGKHHLLCD FVLELYKSSS TEPVDIPPEL CHGIQGKLTL NENAVLPDHI DFKDPQFQED
FVFKAVVLPG AKKPAPVLKP GDWEKTNNNG RPWRPQLGFN RDRRPVHLDQ SAFRTLGFDA
ILYGDSVVKC SKIFSVKLHL YFIKQDCVFD YLRPQESWRG PTPLFQQPPQ RYERNSGAAP
LLSWNRMLQS QGAAFQQNQY QGLGGPMNYP HRPDDRMDRG RQVIKHCVIV LCFLLGHLCS
ICVMGKGKIL TANVSAK
//
