ID M7BZN6_CHEMY Unreviewed; 1020 AA.
AC M7BZN6;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Nucleoporin NDC1 {ECO:0000256|ARBA:ARBA00017534};
DE AltName: Full=Transmembrane protein 48 {ECO:0000256|ARBA:ARBA00031201};
GN ORFNames=UY3_09298 {ECO:0000313|EMBL:EMP33587.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP33587.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- FUNCTION: Component of the nuclear pore complex (NPC), which plays a
CC key role in de novo assembly and insertion of NPC in the nuclear
CC envelope. Required for NPC and nuclear envelope assembly, possibly by
CC forming a link between the nuclear envelope membrane and soluble
CC nucleoporins, thereby anchoring the NPC in the membrane.
CC {ECO:0000256|ARBA:ARBA00025441}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Nucleus membrane
CC {ECO:0000256|ARBA:ARBA00004232}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004232}. Nucleus, nuclear pore complex
CC {ECO:0000256|ARBA:ARBA00004567}.
CC -!- SIMILARITY: Belongs to the NDC1 family.
CC {ECO:0000256|ARBA:ARBA00005760}.
CC -!- SIMILARITY: Belongs to the YIP1 family.
CC {ECO:0000256|ARBA:ARBA00010596}.
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DR EMBL; KB535465; EMP33587.1; -; Genomic_DNA.
DR AlphaFoldDB; M7BZN6; -.
DR STRING; 8469.M7BZN6; -.
DR eggNOG; KOG4358; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR019049; Nucleoporin_prot_Ndc1/Nup.
DR InterPro; IPR006977; Yip1_dom.
DR PANTHER; PTHR13269:SF6; NUCLEOPORIN NDC1; 1.
DR PANTHER; PTHR13269; UNCHARACTERIZED; 1.
DR Pfam; PF09531; Ndc1_Nup; 2.
DR Pfam; PF04893; Yip1; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Nuclear pore complex {ECO:0000256|ARBA:ARBA00023132};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 113..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 94..207
FT /note="Yip1"
FT /evidence="ECO:0000259|Pfam:PF04893"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1020 AA; 114270 MW; 6361557D057A84DA CRC64;
MRCDRRRAVL YSGQSQHSIS GTHDAGERSS EFDDASNLLA GNPDATTISI DEPSENPKNQ
YGLLQDSRRE EDDELLGTDD SDKTEVLDRI KGSVFPIPGK NFVRLYIRSN PDLYGPFWIC
ATLVFAIAIS GNLSNFFIHL GKPAYRYVPE FRKVSIAATA IYAYAWLVPL ALWGFLMWRN
SKVMNIVSYS FLEIVCVYGY SLFIYIPTAW LQPTGHRVGN LKNVNGFLPL TLEFFILENI
SGTDSFNDWY TSYVIFCILL MSVVILIISI FNVEFYAVVP SIPCSRLALL GKIIHPRQVI
HSVVHAIMGM LMAWCAAVMT KGKFQFLALP CTASESLDGA VQHMCLNEYH LFLLLSGAFM
GYNYSLLYLV NNMNYLPFPI IQFLALQDLM LLSQYSPVRR QEVFSLSQPG GHPHNWTAIS
KECLTLLSDL TQKLIMQQEA AATNGRVKQP STGEVGRSLR SSEAAVTEEM AFQTQRYNVV
SRAHIPSLVK SSLLPLKALS TSDLGSSFGS PLSSPALNHK AGILDLNSPW HGSVQSPHVM
RRGPKLWTSS SDLQMNGSPQ ASFPVISIAR VGNEAIQPSF IYTWLQNKQE QVRSFLSKRV
LIMYFFSKHP EALIQAVFSD AQMHIWALEG LSRLVAASFT EDRFGVVQTT LPAILNTLLT
LQEVVDKHFK LPHASSKPPR ISGSLMDTSY KTLRFALRAS LKTAIYRVTT TFGEHLKTPF
SVGCNFAVLE VRVEETRWML PCSLLTYSDL REQLLFPPPR TAACIRDCCV PSSIFTAART
GDKQGPFQQR DTNMHYEVAE FQKPSTSAAF FEAIDKCQVV PMKELPQVTC SNTGKTFLNS
QMSFKITVNN SSDNTEPQQN PHEMSVPLLD LIPKRPSIFE RLPILQRTQE FRCPKSSKEY
FQQQKHQSVK ELFTGTSSKW STTRKRVPNG TGIMFEEGSA LGSKGLSSPQ NRSLHLHFFV
QILLFPHLYL AQGRSSTPQL RWCKLPEGPY ACGVIQSYPS AALTCTEAGQ FGMRELLSVP
//
