ID M7C0U5_CHEMY Unreviewed; 815 AA.
AC M7C0U5;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Spliceosome RNA helicase Ddx39b {ECO:0000313|EMBL:EMP41760.1};
DE Flags: Fragment;
GN ORFNames=UY3_00986 {ECO:0000313|EMBL:EMP41760.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP41760.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB483964; EMP41760.1; -; Genomic_DNA.
DR AlphaFoldDB; M7C0U5; -.
DR STRING; 8469.M7C0U5; -.
DR eggNOG; KOG0329; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR029073; DUF4661.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR018865; STK19-like.
DR PANTHER; PTHR15243; SERINE/THREONINE-PROTEIN KINASE 19; 1.
DR PANTHER; PTHR15243:SF0; SERINE_THREONINE-PROTEIN KINASE 19; 1.
DR Pfam; PF13088; BNR_2; 1.
DR Pfam; PF15576; DUF4661; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF10494; Stk19; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:EMP41760.1};
KW Helicase {ECO:0000313|EMBL:EMP41760.1};
KW Hydrolase {ECO:0000313|EMBL:EMP41760.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000313|EMBL:EMP41760.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 742..761
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 472..617
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 456..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..476
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EMP41760.1"
SQ SEQUENCE 815 AA; 89524 MW; 3870294B2DC59E2A CRC64;
SGAVESALRY LAFLFPRQLF EDALPPLVLK HQLYSLVRDR TAVDRQLSRL KDEGLIRLFQ
LGFDSDVFGV AFTQDYTAKV LQSVAGKEHA GTVRQFLETA LTTCPELSYD NGRMQRDFGF
RDPDITQLVN AGILTVRRKA VLGMIQKAKY KEILLSDLQG RQAPSAVKLG LPYHIHDLIG
AQLVDCYCHQ VPPHLTPTAG YSPSVPPPRP GVSVGARLVC VRRNNQESLG PLSDEACAQI
NSFSSQMPQG LLVPAQGQWG SPDCPGSLEL FGPCCSGQVS PLITLEQLLW VSPLITLEQL
LWVSGREIGE VNTYRIPLIA VTPQGSLLAF AEARKSSPSD SGAKFIALRR STDGGATWSP
NSFIVDDGTQ VDGLNLGAVA VDRANGSVFL FYALCIHQPQ PCISSTMLIR SQDDGLSWSR
PRNLSQDIGL DSKQGLPTER EKIHIFSQRL GRKHQSVMDK TCRRPKPRES GNRRRDRAQI
PSGPVVIFVK SVQRCIALAQ LLVEQNFPAI AIHRGMSQEE RLSRYQQFKD FQRRILVATN
LFGRGMDIER VNIAFNYDMP EDSDTYLHRV ARAGRFGTKG LAITFVSDEN DAKILNDVQD
RFEVNISELP DEIDISSYST VTLGLSKEAP GVSGCSGRGP GITSGHSHFL SSGGPFPVSL
GRFRYAGKMH ADFRCSVLTS VSAVGGLRAL LPPSPDIPEH FQICFNFARH LFDLCVVTLL
CACSPAFRLL LDILGFRGPL KVWLHGLATF LVTTYGMYLA LWLGQKYLLQ FACLYGFLQT
LVLCVSIRAA EEEEESGGVP GGVDPGGGAE AERTE
//
