ID M7C2L1_CHEMY Unreviewed; 1232 AA.
AC M7C2L1;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Bile salt-activated lipase {ECO:0000313|EMBL:EMP34652.1};
GN ORFNames=UY3_08229 {ECO:0000313|EMBL:EMP34652.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP34652.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000256|ARBA:ARBA00005964}.
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DR EMBL; KB532021; EMP34652.1; -; Genomic_DNA.
DR AlphaFoldDB; M7C2L1; -.
DR STRING; 8469.M7C2L1; -.
DR ESTHER; chemy-m7c2l1; Cholesterol_esterase.
DR eggNOG; KOG1516; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR CDD; cd00312; Esterase_lipase; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019826; Carboxylesterase_B_AS.
DR InterPro; IPR019819; Carboxylesterase_B_CS.
DR InterPro; IPR019136; TF_IIIC_su-5_HTH.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR43903:SF9; BILE SALT-ACTIVATED LIPASE; 1.
DR PANTHER; PTHR43903; NEUROLIGIN; 1.
DR Pfam; PF00135; COesterase; 1.
DR Pfam; PF09734; Tau95; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
DR PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 119..147
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 148..175
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 176..203
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 204..231
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 232..259
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 260..288
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 278..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1232 AA; 139609 MW; EAF7EE28D911CE6A CRC64;
MPRSFLVKSK KAHTYHQHHS VEEDLPVSTW DPIPSLCLET SVPALQVKGC SNSTSTPTFY
KPRFSWDAFH SPYSYRQMSS SMQSALLERS VSLYGSHLLP SSEPPIDYSM RYSPDMETYH
CVKCNKVFST PHGLEVHVRR SHSGMRPFAC DVCGKTFGHA VSLEQHTNVH SQERSFECKM
CGKTFKRSST LSTHLLIHSD TRPYPCQYCG KRFHQKSDMK KHTYIHTGEK PHKCQVCGKA
FSQSSNLITH SRKHTGFKPF SCELCAKGFQ RKVDLRRHRE TQHSLNTDEG NKKPCSDSPT
DKKDMMQVEN SFTARRKGAK SCSQLPQGMS DFQYLAMHSG PDSKQISMYD KVLMLKPEKE
EFFNRELPLY IPPPIFSRLD TPIDYFYRPD VQHRDGYNNP QVSCENLIGL SRARRPHNAI
FVNFDDDDIP TKPLEPAVQT WKKVCTNPVD KNVEEELRKL FEIRPVWSRN AVKANISVHP
DKLKLLLPYL AYYMLTGPWR SLWVRYGYDP RKHPEAKIYQ VLDFRIRCGM KYGYAPSDMP
VKAKRSTYNY SLPITIKKPV SHTVSVQDLK HGLDTSNTSN AKKPASSRYK LKDSIYIFQE
GDLPPYRQMF YQLCDLNVDS LQKIIHRNDG TEAECTERDG WCLQKTSDDL RDTMSLMIKQ
IIRSTRPEIK DLLGPIESFI LHSPIPNQCK IVAWPILGVV YTEGGFVEGI SEKLGLFGDY
VDIFKGIPFA APPKSFEDPQ QHPGWDGTLK AKEYKNRCLQ VTLTQTSTRG SEDCLYLNIW
IPQDRKGVST NLPVMIWIYG GGFLVGGGQG ANFLANYLYD GQEIAVRGKV IVVTFNYRVG
PLGFLSTGDA SIPGNYGLKD QHMAIAWVKR NIKAFGGDPE NITIFGESAG AASVSLQTLS
PYNKGLIKRG ISQSGVGLCP WAIQENPLFW ATKVAEKVGC PTDNTTAMGN CLRVTDPQAV
TLAYYLPMVN LQYPLVYYLS FIPVVDGDFL PDRPENLFAN AADIDYIAGV NNMDGHFFAG
FDMPAINRPL VKITADEVYN LVQGLTLQKG VQAANAAFSL YSQLWNDKPD QEVMKRTVVD
LETDYLFLSP TQQALALHNA NARNAKTYSY VFSQPSRMPV YPSWVGADHA DDLQYVFGKP
FSTPLGYWPK HRTVSKALIA YWTNFARTGD PNKGESTVPI GWIPYTQEES FYLEINSDIN
YDSVKQGLRA SYVQFWNTTY QSLPDLSLPF LD
//
