ID   M7C343_CHEMY            Unreviewed;       873 AA.
AC   M7C343;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Inter-alpha-trypsin inhibitor heavy chain H5 {ECO:0000313|EMBL:EMP38828.1};
GN   ORFNames=UY3_03952 {ECO:0000313|EMBL:EMP38828.1};
OS   Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC   Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX   NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP38828.1, ECO:0000313|Proteomes:UP000031443};
RN   [1] {ECO:0000313|Proteomes:UP000031443}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA   White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA   Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA   Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA   Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT   into the development and evolution of the turtle-specific body plan.";
RL   Nat. Genet. 45:701-706(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the ITIH family.
CC       {ECO:0000256|ARBA:ARBA00010158}.
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DR   EMBL; KB518472; EMP38828.1; -; Genomic_DNA.
DR   AlphaFoldDB; M7C343; -.
DR   STRING; 8469.M7C343; -.
DR   eggNOG; ENOG502QPS2; Eukaryota.
DR   Proteomes; UP000031443; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR   CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR010600; ITI_HC_C.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR10338:SF62; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H5; 1.
DR   Pfam; PF06668; ITI_HC_C; 1.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          1..113
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          231..415
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          65..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          570..601
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..85
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   873 AA;  97018 MW;  196A9BE13CBEA322 CRC64;
     MAEFTVKSTI ISRYAFTTVS CTMVNSGFEA KEGTFEMQIP AAAFISNFTM IIGDRIYHGE
     VTAKEKKTSN EDKQRNNKHS SPTDGGENRA ETFKASGTIP RKTHAIFMLH YEELLQRHLG
     KYEYTVSVRP QQLVGRLRVE VNILENSGFS SLEVLPLQNS KQRGIKKVIG PILLPLRYMV
     NLLTSLGAGP CPPVASSKGV LVMGVVDIIV ILNGYFVHYF APQNLPPLPK NVVFVLDSSA
     SMVGAKLRQT KDALFTILRD LRPEDHFNIV GFSDRIKVWQ KDHLEPVTPN NIRDAKKYIH
     NISPTGGTNI NEAVQTSAKL LNNYIAQNDI DARSVSLIIF LTDGRPTVGE MQSSKILSNT
     KEAIREKFCL FTIGIGNDVD YKLLERMSLE NCGMMRQIQE DEDAAAQLKG FYDEIGTPLL
     SDIRVDYPKD SVEQVTQNLF PNYFNGSEIV IAGKLIERNS GKLHVEVTAS NANKYILLKT
     DVAIDVPSKN DIRGSPGMED GKEAQNYAER AWSYLTIKEL LTSWLKSDDS EERQHLMDKA
     KSLALTYNFI TPFTSLKMKE LQADRPKEIH ASPSTEGIGE TVQSLQGHKV PPGVSKQPDK
     ERIKISKTSA DGDPHFVIDF PSSKLAVCFN IDGQPGDILR LVSDHNESGV TVNGQLIGAP
     APPNGHKKQR TYFTTITILS NKPERSYVEI TPTKVILDDG ERLILPCDRS ATVGSSGLEV
     SIFANSNVTV AIHGTISFII LIHQYKNPAP YQRNHLGFYI SNSKGLSPHS HGLLGQFLYH
     EVKLTQDPLG GSPQLVSQNS TEEPNPRPVN VLKVKGRLVP VVWKQRKIYN GEQEVDCWFA
     KNNADKLIDG DYKDYLAAHP FDTGTSFGMA NRL
//