ID M7C539_CHEMY Unreviewed; 179 AA.
AC M7C539;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Coiled-coil-helix-coiled-coil-helix domain-containing protein 6 {ECO:0000313|EMBL:EMP35612.1};
GN ORFNames=UY3_07230 {ECO:0000313|EMBL:EMP35612.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP35612.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC the mitochondrial inner membrane that plays crucial roles in the
CC maintenance of crista junctions, inner membrane architecture, and
CC formation of contact sites to the outer membrane.
CC {ECO:0000256|ARBA:ARBA00002689}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004635}. Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00034476}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00034476}.
CC -!- SIMILARITY: Belongs to the MICOS complex subunit Mic19 family. Metazoan
CC Mic25 subfamily. {ECO:0000256|ARBA:ARBA00034480}.
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DR EMBL; KB528245; EMP35612.1; -; Genomic_DNA.
DR AlphaFoldDB; M7C539; -.
DR STRING; 8469.M7C539; -.
DR eggNOG; KOG4083; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0061617; C:MICOS complex; IEA:InterPro.
DR InterPro; IPR007964; MIC19/MIC25.
DR InterPro; IPR042860; MIC25.
DR PANTHER; PTHR47609; MICOS COMPLEX SUBUNIT MIC25; 1.
DR PANTHER; PTHR47609:SF1; MICOS COMPLEX SUBUNIT MIC25; 1.
DR Pfam; PF05300; MIC19_MIC25; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443}.
FT REGION 1..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 179 AA; 19902 MW; 6C05F9DCEF484FD8 CRC64;
MSFQTGEVNG MKRLSEDVVN RMKETSQLKG DKRPSSFPSP SSYGTASSPQ AAKGKPKCTT
GIHPPTTSSS GQKPSEAEEE LYKRYEQEQA LVQEELLRLA KREREAGSEC LNTTLQREKN
STNEERQKAT RMAPLPRAGG GSVPWFLTTT CPALTVRALR RYKICNRIRA AICRNGPRI
//
