ID M7CAT1_CHEMY Unreviewed; 1331 AA.
AC M7CAT1;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=2-hydroxyacylsphingosine 1-beta-galactosyltransferase {ECO:0000313|EMBL:EMP41798.1};
GN ORFNames=UY3_00954 {ECO:0000313|EMBL:EMP41798.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP41798.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000256|ARBA:ARBA00009995}.
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DR EMBL; KB483075; EMP41798.1; -; Genomic_DNA.
DR STRING; 8469.M7CAT1; -.
DR eggNOG; KOG2992; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005730; C:nucleolus; IEA:UniProt.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR007718; Srp40_C.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR PANTHER; PTHR48043:SF161; 2-HYDROXYACYLSPHINGOSINE 1-BETA-GALACTOSYLTRANSFERASE; 1.
DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR Pfam; PF05022; SRP40_C; 1.
DR Pfam; PF00201; UDPGT; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS00375; UDPGT; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000313|EMBL:EMP41798.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EMP41798.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 725..748
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 760..779
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1275..1299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 621..693
FT /note="Srp40 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05022"
FT REGION 67..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1331 AA; 142405 MW; 14EDD91E022D41DF CRC64;
MAPSSAPMGA AGAVPVDGAV CKATWLHLRL GAREWTCHCF WEPLETDQDP NAASLLDVFN
YWLKSPDAKK RKAVPNGPPA KKSKKESSSS SDESSSEEDE KTTAKKPATK SAPVPKVIAK
AAAPAKKAES SSEDSSDDSD SEEEEKKPAQ KVTKAQAKPA ATKTQPQKKA KSSSSSDTSS
SEDERPKKQL LKPVAAKTAA KSAGSKAACN AANGKAESSS SSSSEDSDKE KAASAKAVPK
KTPLPKPAAI QVPSGKGRAP AKESSSSEDS SDSSEDEKPA SKSKPKPGPY SAVPPPQVTE
PRKGKAKPSV AKAPGKKAES SDSSDSSSDS SDEMEQTPKK GTTAKASLAK KKPTPTPTAV
TIKKGGSSSD SDSDSSSEEE KVVTKLTAKS LAAKGPAKPA KVPAKSGQAK KGSSSSSDSS
DSDSSEDETP AKPAVKPAPP AAKKPPAVAK KAQSSSDSDS SSSSSEEEKK APPAKPASKT
AKPASKPCTL VPKASSSDSD SSSSEEEQSK PAVKPASKSP GGSKACAGKK AAAASSSSSS
SDSSSDDDKK SRTAGTPVAG LKPGKGGQNN SSLVKEKPKA SSTPAAKSPA TKKSEPKPAG
GSESSSESSC DEKGKANGAV PFRRVREEEI EVDSRVANNS FDAKKGAAGD WGEKAHNVLK
FTKGKSFRHE KTKKKRGSYC GGAISTQVNS IKFEIQKWMD GGLDTSLPMV RALGPKFPVN
CMHNIVSTFC LVTFALVVCY SITTDVFFSL VATLQWQNYA YCFSFCKLVI TTLVTFLRAT
GEAATRLLRH SNCAKAQSPS TEMRLPPHPV AVLLMVATFS LDCCHGAKVL VMPTIVFDSH
LRVFMRVAEA LNDRGHNATL LLHEGRESEP FLPGLRVQTY RGIFSMESAD AWVQEKIKRV
FQGKKTSLEI FSFLEKYLEN CDLVLGDAAL LQQLRGEGFD LFLVDPNEMC GFILAHLLGI
KYAVISTGFW YPAEIGATSP VAYVPEFNSL MTDRMGLVGR TWNLLVYMIT RIATKLVILP
KFDRLMQKHG VEPQKSMLEL VYGTSLFFLC NDVVLDFPRP TLPHVIFTGG ILAEPEKPLP
VGLRLWVEAA DAGVVVVSFG IGIRALPSNL VEKMAGAFAR LPQRVVWRYF GQKPNNLGEN
TLMMEWLPQN DLLGHPNVKA FVSHCGMNGI FEAIYHGVPV VGFPFYGDQF DIMTRVQAKG
MGILMDWSRV SEEDLYQAIV TVLSKPSYNK AAKQISALHR DTPMHALNRT VYWLEYILRH
DGAPYLRPAV YDLSFYEYFC LDILALFLLC LAGAAYALSK AIVWYRGKRA SPVHLNGNCL
NGHLVEGKKA Q
//
