ID M7N8X5_9BACL Unreviewed; 1172 AA.
AC M7N8X5;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd_2 {ECO:0000313|EMBL:EMR05053.1};
GN Synonyms=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=C772_02975 {ECO:0000313|EMBL:EMR05053.1};
OS Bhargavaea cecembensis DSE10.
OC Bacteria; Bacillota; Bacilli; Bacillales; Planococcaceae; Bhargavaea.
OX NCBI_TaxID=1235279 {ECO:0000313|EMBL:EMR05053.1, ECO:0000313|Proteomes:UP000011919};
RN [1] {ECO:0000313|EMBL:EMR05053.1, ECO:0000313|Proteomes:UP000011919}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSE10 {ECO:0000313|EMBL:EMR05053.1,
RC ECO:0000313|Proteomes:UP000011919};
RX PubMed=23766406;
RA Shivaji S., Ara S., Begum Z., Ruth M., Singh A., Kumar Pinnaka A.;
RT "Draft Genome Sequence of Bhargavaea cecembensis Strain DSE10T, Isolated
RT from a Deep-Sea Sediment Sample Collected at a Depth of 5,904 m from the
RT Chagos-Laccadive Ridge System in the Indian Ocean.";
RL Genome Announc. 1:e00346-13(2013).
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR05053.1}.
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DR EMBL; AOFT01000023; EMR05053.1; -; Genomic_DNA.
DR RefSeq; WP_008301239.1; NZ_AOFT01000023.1.
DR AlphaFoldDB; M7N8X5; -.
DR STRING; 1235279.C772_02975; -.
DR PATRIC; fig|1235279.3.peg.2973; -.
DR eggNOG; COG1197; Bacteria.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000011919; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000011919}.
FT DOMAIN 636..797
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 818..972
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1172 AA; 130650 MW; 16F746C72E7A4940 CRC64;
MEELLDVLAG GGEIADLLGD LKEGRDRQLV TGLAGGARAA LFALAARETG RPVLVVEPNM
LQAQRTYEDL ARLSGEESVR LYPADELTAA ELSVASPELR AQRIEALDHL MRNGTGIFVT
PIAGLRKLLP APADWKNAAL SAELGDEIDP ADWAASLVAM GFSRQPMVTS PGEFSLRGGI
LDIYPLDLEE PVRFELFDTE IDSIRTFSAD DQRSTGRLDT VRILPAHEFS WPAERLAVTA
DRLEASLAAS LKKVSDEAAR EALLENIGAD IALMKDGEIP EGVMKYASLA GETAFLGDYF
PEEGILFYNE AGRIIEVAES LERQEGEWHT EMIASGKLVH DARLSHTFKE IDAMAGQKKV
YLSLFSRSLP GLVLKDTVQI SCKPMQQFHG QMNLLKSEAE RWQAGGFTVL LLAGDRERAE
KVRSILGDYG MEADIPEEGT VPGSGIHVIE GDLSDGFELP LRQIAVVTDS ELFKQRSRRK
ARPQKLSNAE RIKSYSEIKP GDYVVHIQHG IGKYIGIETL DVGGTHKDYL HISYRGDDKL
YVPIDQIDQI QKYVGSEDRE PKIHKLGGTE WKKTKSKVSK AVKDIADDLI KLYAKREAEK
GFAFSPDDDL MHSFEASFPY DETDDQLRSI EEIKRDMERE RPMDRLLCGD VGYGKTEVAI
RAAFKAVGDG KQVAFLVPTT ILAQQHFETM KERFAGYPVE VRMLSRFGTR KEHQETVKGL
KDGTVDVVVG THRLLSKDVE YRDLGLLIVD EEQRFGVTHK ERIKQMKANV DVLTLTATPI
PRTLHMSMIG VRDLSVLETP PANRFPVQTY VMEFSGPLVR EAIEREMARG GQVFYLYNRV
EDMARKAEEI QMLVPEARIA TAHGRMSETE LEAVILAFLE GEYDVLVTTT IIETGVDIPN
VNTLIVHDAD RMGLAQLYQL RGRVGRSNRV AYAYFLYQRN KVLTDVAENR LQAIKEFTEL
GSGFKIAMRD LSIRGAGNLL GAQQHGFIDS VGFDMYSKML EEAIEEKRGN GKEEEVPDVE
VTLHTDAYFP DSFIPDGFQK IQMYKRVKAV ATEEDYSELV DEMADRFGDL PLEAEQLLKV
ALMKVWAREA GVESIKQQGD RVIISFTEAG TQQADGAKIM EDTLQYGRAV GFHVEDGRLL
LTVDGSKTGK KTLFDVLEGV MKILPDAKKQ EV
//
