ID M7NI21_PNEMU Unreviewed; 605 AA.
AC M7NI21;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=ENTH domain-containing protein {ECO:0000259|PROSITE:PS50942};
GN ORFNames=PNEG_03378 {ECO:0000313|EMBL:EMR08208.1};
OS Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent)
OS (Pneumocystis carinii f. sp. muris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1069680 {ECO:0000313|EMBL:EMR08208.1, ECO:0000313|Proteomes:UP000011958};
RN [1] {ECO:0000313|Proteomes:UP000011958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B123 {ECO:0000313|Proteomes:UP000011958};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR08208.1}.
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DR EMBL; AFWA02000017; EMR08208.1; -; Genomic_DNA.
DR RefSeq; XP_007875462.1; XM_007877271.1.
DR AlphaFoldDB; M7NI21; -.
DR STRING; 1069680.M7NI21; -.
DR GeneID; 19897065; -.
DR VEuPathDB; FungiDB:PNEG_03378; -.
DR eggNOG; KOG0251; Eukaryota.
DR HOGENOM; CLU_014248_1_0_1; -.
DR OMA; NIAYEPS; -.
DR OrthoDB; 1424668at2759; -.
DR Proteomes; UP000011958; Unassembled WGS sequence.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:InterPro.
DR GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0048268; P:clathrin coat assembly; IEA:InterPro.
DR GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
DR CDD; cd16988; ANTH_N_YAP180; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 1.20.58.150; ANTH domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR014712; ANTH_dom_sf.
DR InterPro; IPR045192; AP180-like.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR PANTHER; PTHR22951; CLATHRIN ASSEMBLY PROTEIN; 1.
DR PANTHER; PTHR22951:SF89; PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP; 1.
DR Pfam; PF07651; ANTH; 1.
DR SMART; SM00273; ENTH; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50942; ENTH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011958}.
FT DOMAIN 1..146
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT REGION 311..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 605 AA; 68694 MW; 2F277096CF19DBB4 CRC64;
MPYKALSYQK AVNGATKIKL AAPKQKYLER ILGATYSGDI ALFEVFSALF SRLREPSWTI
VFKSLIVIHI MIRDGSRDIT LQYLSNNMRY FSIKELFGDT SFFSYDSGGL LFLGELAISQ
QSRNIQNYGL YLQEKIQSFK DVQVDYVYAK SSKTIEGRLR RLTVAKGLLR EVEIVQRQID
TLLCCKFLED GLTNNITIVA FRLLIGDLLS LFQVINEGVI NVLEHYFEMS RYDAEKALEI
YKKFVKQTAN VSDYLSFACR METLTCIEVP NIKHAPVGLS RALQEYLDDK NFEKNRLQYI
ENKNALDSSK KKANLTVPSA KTSSKKKTTD TQSLSGNTQK QNSNNINLID FFSSIENEQA
FMFPSAPMKN IAYEPSNFSG IQPTQPIQPI QTVVNSAPEE QSIVSFPQNV PSQMQPQVQV
SYGLYNQYSS AFHPNNAPYQ STQPIMQNPN SFQASFPINQ KQDYNSIYPM QANFSGSAYG
IYHMQSNAHP FNQTHHFNQI VPSPVLETNN SSINHTNPFH RPPLSMNTEF EHQRTLLTNQ
FPPTITSTQF PPPTNPFSKS YDNVTTPFLD PKARTVRQNA STLPFAQKPR TNPFSNDNLP
SEHGK
//
