ID M7NUH8_PNEMU Unreviewed; 546 AA.
AC M7NUH8;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=U4/U6.U5 tri-snRNP-associated protein 2 {ECO:0000313|EMBL:EMR10957.1};
GN ORFNames=PNEG_01102 {ECO:0000313|EMBL:EMR10957.1};
OS Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent)
OS (Pneumocystis carinii f. sp. muris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1069680 {ECO:0000313|EMBL:EMR10957.1, ECO:0000313|Proteomes:UP000011958};
RN [1] {ECO:0000313|Proteomes:UP000011958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B123 {ECO:0000313|Proteomes:UP000011958};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR10957.1}.
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DR EMBL; AFWA02000003; EMR10957.1; -; Genomic_DNA.
DR RefSeq; XP_007873014.1; XM_007874823.1.
DR AlphaFoldDB; M7NUH8; -.
DR STRING; 1069680.M7NUH8; -.
DR GeneID; 19894799; -.
DR VEuPathDB; FungiDB:PNEG_01102; -.
DR eggNOG; KOG2026; Eukaryota.
DR HOGENOM; CLU_016848_4_0_1; -.
DR OMA; LNVYCCL; -.
DR OrthoDB; 719409at2759; -.
DR Proteomes; UP000011958; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000245; P:spliceosomal complex assembly; IEA:InterPro.
DR CDD; cd02669; Peptidase_C19M; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR033809; USP39.
DR InterPro; IPR028889; USP_dom.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001607; Znf_UBP.
DR PANTHER; PTHR21646:SF16; U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2; 1.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF02148; zf-UBP; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Reference proteome {ECO:0000313|Proteomes:UP000011958};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 218..538
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
SQ SEQUENCE 546 AA; 64475 MW; C1AD966AAE84B2D4 CRC64;
MKSNLLKMLK RKISEDFETS IHKEKLEYQE KNKKEKGDNL FLGKKDDFKR DNLTVSNNLE
QIDENIKKKK EKIESLPTPP LNMYLDTERW IEHDWILILK NYVQFLYRIS MFMHALYAGN
TFKEFLLFFA IFFLIELGRG RSSHAYFHSL DEAHHVYINL HNLKIYVLPE SYEVHTNALD
DIKYVLNPTY TKEQVIAMDM NIEPSYDLDN KRYLPGFVGL NNIKQNNYLN CVIQALSHIT
PFRNYFILEN FDGKSELVQR LSILIRKIWN AKAFRGHVSP HELLQEVSSV SGKQFKLTEQ
SDPLKFLSWL LNIIHRDLGR SKTKVKSSII HRIFQGRVRI QSQQIIAKSD ANDADRLRFE
IGREIKENIL PFLFLTLDLP LPPLFQDEFE DNIIPQVALS TLLAKYDGIT SQELSGQRKR
YKIVKLPPFL IFHIKRFTKN NWRNEKNPTI VNFPIKDLDM RGYIDPIPPP NVSTVYDLSA
NIVHETVSSM EGDKRVFRTQ VRNKSNDTWY QIQDLFVEEI PKEMIFLGES YIQIWERRNH
KKKAND
//
