ID M7NWE4_PNEMU Unreviewed; 833 AA.
AC M7NWE4;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PNEG_00057 {ECO:0000313|EMBL:EMR11617.1};
OS Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent)
OS (Pneumocystis carinii f. sp. muris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1069680 {ECO:0000313|EMBL:EMR11617.1, ECO:0000313|Proteomes:UP000011958};
RN [1] {ECO:0000313|Proteomes:UP000011958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B123 {ECO:0000313|Proteomes:UP000011958};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR11617.1}.
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DR EMBL; AFWA02000005; EMR11617.1; -; Genomic_DNA.
DR RefSeq; XP_007871912.1; XM_007873721.2.
DR AlphaFoldDB; M7NWE4; -.
DR STRING; 1069680.M7NWE4; -.
DR GeneID; 19893755; -.
DR VEuPathDB; FungiDB:PNEG_00057; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_340685_0_0_1; -.
DR OMA; FCELARI; -.
DR OrthoDB; 2722913at2759; -.
DR Proteomes; UP000011958; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113:SF327; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP, ISOFORM E; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000011958}.
FT DOMAIN 353..478
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 519..783
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 833 AA; 95990 MW; 4DD6727AC8955599 CRC64;
MSELRRKGIK NGDFVLSGKE RNIGGRQMAE INKNETLKMS FFKGTHFRQF QDRMPLNKKN
TETGNESKIW SSNIKRKSHS FRPNYYKYKK KSRNILKRSI STECLDNISL PFTASSSIAR
FSSLSLPIAF HNTVQDSSLY GHDFEHSSGT FRKKISLSKQ PKYAPFLFYS LATTEIAKPN
ISSIVFSTIS IMQTIGLPSF IIRSMITEQD LYALRELWIR RQAAKHGFDI TNILNRPYSI
STNPSILTLP TLISPSFSEI SVFESDSEDN KSLKDASKKF KTKKSWSNFI RFKQPLQLNS
NKSKLRKKRN VSYMIYGSCK TEEEIFNLSE NTILHIQDDM GFDVLVTAKN HSKRYILIAG
TIDCLVAQCS LSLNKTLDHD HVELLIRSFS FFCTITQFLK IIINQFRVSF RNPNGKVARS
RISSVLTKWL AIQPEDICRN STAYEMFYMF IEEVKFCGCF FEAEQCETIL KAQLALLESR
RAFYKRNFHL NFQRELASFY KFSKGKLKLV GNLPSIFLNP FTVAKYLAVM DYILSRDAVD
FAAIKLYWHK RGTLDSRKKK LVDKIDRFVR RTAMLAHWIA VEILQQNSSE KRAKTICWFI
DIAKNLYHLN DFHSTIIITN VLINPPVKTL YQTWAAVPSS YIAFMDTLKN LACHSDGMIA
YRKLLTQSKS TTIPYFALYL EDMSSITNLP TYISSVIPGH STEKHFVANV SVLPSLASLI
PRNVDPEMIN LQKFRAFCKE VNTFLNYLSE PYPFYLELDC NSYGLQLYPI FNPISISHKT
IPTGSLNYIS EIIDKALLYA WTLSENDDII HVENPQLLVL TKLLEMTGEN YSF
//
